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Nuclear morphology is shaped by loop-extrusion programs

It is well established that neutrophils adopt malleable polymorphonuclear shapes to migrate through narrow interstitial tissue spaces1–3. However, how polymorphonuclear structures are assembled remains unknown4. Here we show that in neutrophil progenitors, halting loop extrusion—a motor-powered process that generates DNA loops by pulling in chromatin5—leads to the assembly of polymorphonuclear genomes. Specifically, we found that in mononuclear neutrophil progenitors, acute depletion of the loop-extrusion loading factor nipped-B-like protein (NIPBL) induced the assembly of horseshoe, banded, ringed and hypersegmented nuclear structures and led to a reduction in nuclear volume, mirroring what is observed during the differentiation of neutrophils. Depletion of NIPBL also induced cell-cycle arrest, activated a neutrophil-specific gene program and conditioned a loss of interactions across topologically associating domains to generate a chromatin architecture that resemble ....

Elie Metchnikoff , Ok Organization , Cell Biol , Untersuchungen Des , Cornelia De Lange , Acids Res ,

Probiotics and their health benefits (3)

Probiotics and their health benefits (3)
punchng.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from punchng.com Daily Mail and Mail on Sunday newspapers.

Osun State , United States , United Kingdom , Elie Metchnikoff , Olatide Modupe , Obafemi Awolowo University , Malabar Coast ,

Probiotics and their health benefits (1)

If you have recently had an illness or treatment that weakened your microbiome, probiotics will help rebuild it. ....

Carolyn Newberry , Elie Metchnikoff , Agriculture Organisation , Health Benefits Of Probiotics , United Nations , Presbyterian Weill Cornell Medical Center , European Food Safety Authority , World Health Organisation , Weill Cornell Medical , Georgia Giannopoulos , Health Benefits ,

How Bulgarian Yogurt Became A Dietary Sensation In Japan

How Bulgarian Yogurt Became A Dietary Sensation In Japan
menafn.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from menafn.com Daily Mail and Mail on Sunday newspapers.

France General , King Francis , Stamen Grigorov , Elie Metchnikoff , Meiji Holdings , Nobel Prize Winning Russian ,

The secret of Bulgarian yogurt - The Street Journal

The secret of Bulgarian yogurt - The Street Journal
thestreetjournal.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thestreetjournal.org Daily Mail and Mail on Sunday newspapers.

Sofiya Grad , Kharkivs Ka Oblast , Dimitar Vitanov , Rachel Stewart , Elie Metchnikoff , Stamen Grigorov , Ilya Metschnikov , European Union , University Of Geneva , Nobel Prize Winning , Kharkiv Oblast , Central Asia ,