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A drug target for erectile dysfunction to help improve fertility, sexual activity, and wellbeing: mendelian randomisation study

Objective To investigate the association of genetically proxied (using a surrogate biomarker) inhibition of phosphodiesterase 5 (PDE5), an established drug target for erectile dysfunction, with fertility, sexual behaviour, and subjective wellbeing.

Design Two sample cis-mendelian randomisation study.

Setting Summary data on genetic associations obtained from the International Consortium for Blood Pressure and UK Biobank.

Participants Individuals of European ancestry from the International Consortium for Blood Pressure (n=757 601) for estimating PDE5 inhibition (using the surrogate biomarker of diastolic blood pressure reduction), and UK Biobank (n=211 840) for estimating the fertility, sexual behaviour, and subjective wellbeing outcomes in male participants.

Intervention Genetically proxied PDE5 inhibition.

Main outcome measures Number of children fathered, number of sexual partners, probability of never having had sexual intercourse, and subjecti ....

United Kingdom , City Of , Dipender Gill , Benjamin Woolf , James Yarmolinsky , Skanda Rajasundaram , Stephen Burgess , Care Research Cambridge Biomedical Centre , Centre Research Ethics Committee , National Institute For Health , Research Council South West Doctoral Training Partnership , Research Council , Regional Development Agency , Novo Nordisk Foundation , Computing Research Centre , British Heart Foundation , Department Of Health , Cancer Research United Kingdom , International Consortium For Blood Pressure , Innovation Medical Research Council , Doctoral Training Partnership , United Kingdom Research , Research Council Integrated Epidemiology Unit Open , University Of Bristol , International Consortium , Blood Pressure ,

Race to be selected as Barrow Labour candidate hotting up

Race to be selected as Barrow Labour candidate hotting up
nwemail.co.uk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from nwemail.co.uk Daily Mail and Mail on Sunday newspapers.

United Kingdom , City Of , Manju Shahul Hameed , Tmichelle Scrogham , Chris Altree , Erica Lewis , Barrow Branch , Office At Liverpool City Council , Lancaster City Council , Regional Development Agency , Liverpool John Moores University , Conservative Simon Fell , Surrounding Areas , Lancaster City , Tris Brown , Liverpool City Council , Northwest Regional Development ,

List of names of potential Barrow Labour candidate revealed

A LIST of people who could fight the next general election for Labour in Barrow and Furness has been put together. ....

United Kingdom , City Of , Michael Crick , Manju Shahul Hameed , Tmichelle Scrogham , Simon Fell , Chris Altree , Erica Lewis , Office At Liverpool City Council , Lancaster City Council , Regional Development Agency , Liverpool John Moores University , Tris Brown , Furness Labour , Councillor Michelle Scrogham , Business Improvement , Lancaster City , Liverpool City Council , Northwest Regional Development ,