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Objective To investigate the association of genetically proxied (using a surrogate biomarker) inhibition of phosphodiesterase 5 (PDE5), an established drug target for erectile dysfunction, with fertility, sexual behaviour, and subjective wellbeing.
Design Two sample cis-mendelian randomisation study.
Setting Summary data on genetic associations obtained from the International Consortium for Blood Pressure and UK Biobank.
Participants Individuals of European ancestry from the International Consortium for Blood Pressure (n=757 601) for estimating PDE5 inhibition (using the surrogate biomarker of diastolic blood pressure reduction), and UK Biobank (n=211 840) for estimating the fertility, sexual behaviour, and subjective wellbeing outcomes in male participants.
Intervention Genetically proxied PDE5 inhibition.
Main outcome measures Number of children fathered, number of sexual partners, probability of never having had sexual intercourse, and subjecti ....
A high blood caffeine level might curb the amount of body fat a person carries and their risk of type 2 diabetes, suggests research by the Karolinska Institute, University of Bristol and Imperial College, London, and published in the open access jour ....
New research suggests that higher levels of caffeine could help curb body fat and reduce the risk of developing type 2 diabetes, although doctors warn of potential risks. ....