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Polygenic risk scores identify high-risk individuals in European and Asian ancestry, but less so

Polygenic risk scores identify high-risk individuals in European and Asian ancestry, but less so
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Eteläuomen Läi , United States , United Kingdom , Pixabay Gerd Altmann , Nina Mars , Yen Chena Feng , Samuli Ripatti , University Of Helsinki , Institute For Molecular Medicine Finland , Gerd Altmann , South Asian , East Asian , Cell Genomics , Molecular Medicine Finland , Professor Samuli Ripatti , Sini Kerminen , Nature Reviews Genetics ,

University of Helsinki: Polygenic risk scores identify high-risk individuals in European and Asian ancestry, but less so in African ancestry

An international reseach consortium led by the University of Helsinki has performed the largest study to date evaluating transferability of genome-wide polygenic risk scores across ancestries. Polygenic risk scores (PRS) measure genetic disease susce ....

Eteläuomen Läi , United States , United Kingdom , Nina Mars , Samuli Ripatti , University Of Helsinki , Institute For Molecular Medicine Finland , South Asian , East Asian , Cell Genomics , Molecular Medicine Finland , Professor Samuli Ripatti ,

Novel genomic tools increase accuracy of breast cancer risk assessment

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Novel genomic tools increase accuracy of breast cancer risk assessment
Findings from the FinnGen study encompassing 120,000 women indicate that inherited breast cancer risk should be assessed in an increasingly comprehensive manner. Currently, only individual gene mutations are taken into consideration in breast cancer therapy and prevention. The study demonstrates that more extensive genomic data can be used to identify women who are at high risk of breast cancer with considerably greater accuracy. Such knowledge can especially improve risk assessment among the close relatives of breast cancer patients.
In women, breast cancer is the most commonly diagnosed cancer and the leading cause of cancer-related deaths. Genetic predisposition is one of the key risk factors associated with the disease. ....

Eteläuomen Läi , Jaakko Kaprio , Tuomo Meretoja , Mark Daly , Nina Mars , Samuli Ripatti , Aarno Palotie , Heikki Joensuu , Briotta Parolo , Nature Communications , University Of Helsinki , Molecular Medicine Finland , Professor Samuli Ripatti , Elisabeth Wid , Sini Kerminen , Matti Pirinen , Priit Palta , குறி டேலி , நினா செவ்வாய் கிரகம் , இயற்கை தகவல்தொடர்புகள் , பல்கலைக்கழகம் ஆஃப் ஹெல்சின்கி , மூலக்கூறு மருந்து பின்லாந்து ,

Novel genomic tools increase the accuracy of breast cancer risk assessment

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IMAGE: Clinical gene panel tests identify moderate-risk mutations (including mutations in the CHEK2 gene), and high-risk mutations (including mutations in genes PALB2, BRCA1, and BRCA2). However, moderate to high polygenic risk.
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Credit: Nina Mars, University of Helsinki
In women, breast cancer is the most commonly diagnosed cancer and the leading cause of cancer-related deaths. Genetic predisposition is one of the key risk factors associated with the disease.
A study coordinated by University of Helsinki researchers examined the risk of developing the disease on both the population level and in individual carriers of specific gene defects which significantly increase breast cancer risk. The results, published today in the journal ....

Eteläuomen Läi , Mark Daly , Nina Mars , Samuli Ripatti , Nature Communications , University Of Helsinki , Molecular Medicine Finland , Professor Samuli Ripatti , குறி டேலி , நினா செவ்வாய் கிரகம் , இயற்கை தகவல்தொடர்புகள் , பல்கலைக்கழகம் ஆஃப் ஹெல்சின்கி , மூலக்கூறு மருந்து பின்லாந்து ,

Extensive genomic data can improve breast cancer risk assessment

Extensive genomic data can improve breast cancer risk assessment
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Eteläuomen Läi , Mark Daly , Nina Mars , Samuli Ripatti , Emily Henderson , Nature Communications , University Of Helsinki , Molecular Medicine Finland , Professor Samuli Ripatti , குறி டேலி , நினா செவ்வாய் கிரகம் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , பல்கலைக்கழகம் ஆஃப் ஹெல்சின்கி , மூலக்கூறு மருந்து பின்லாந்து ,