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Polygenic risk scores identify high-risk individuals in European and Asian ancestry, but less so

Polygenic risk scores identify high-risk individuals in European and Asian ancestry, but less so
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Eteläuomen Läi , United States , United Kingdom , Pixabay Gerd Altmann , Nina Mars , Yen Chena Feng , Samuli Ripatti , University Of Helsinki , Institute For Molecular Medicine Finland , Gerd Altmann , South Asian , East Asian , Cell Genomics , Molecular Medicine Finland , Professor Samuli Ripatti , Sini Kerminen , Nature Reviews Genetics ,

Researchers successfully determine annual changes in genetic ancestry within Finland


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Commercially available gene tests that shed light on individual s origins are popular. They provide an estimate of the geographic regions where one s ancestors come from. To arrive at such an estimate, the genetic information of an individual is compared to information pertaining to reference groups collected from around the world.
The findings now made by researchers from the University of Helsinki, Aalto University and the Finnish Institute for Health and Welfare make it possible, for the first time, to make similar comparisons within Finland.
A research group at the University of Helsinki, headed by Associate Professor Matti Pirinen, who directed the study, has already earlier produced very detailed information on genetic structure in Finland. In the recently published study, reference groups were compiled from Finns with similar genetic ancestry and then applied to track the effects of migration in the 20th century on the population level. ....

Uusimaa Region , Varsinais Suomi , Southwest Finland , Eteläuomen Läi , Ostrobothnia Region , University Of Helsinki , Aalto University , Finnish Institute For Health , Finnish Institute , Associate Professor Matti Pirinen , Sini Kerminen , Molecular Medicine Finland , Soviet Union , Associate Professor , Medicine Health , Immigrants Migration , ஊசிமா பகுதி , தென்மேற்கு பின்லாந்து , ஒஸ்திரோபோடஞிய பகுதி , பல்கலைக்கழகம் ஆஃப் ஹெல்சின்கி , ஆல்டோ பல்கலைக்கழகம் , பின்னிஷ் நிறுவனம் க்கு ஆரோக்கியம் , பின்னிஷ் நிறுவனம் , மூலக்கூறு மருந்து பின்லாந்து , சோவியத் தொழிற்சங்கம் , இணை ப்ரொஃபெஸர் ,

New data visualization provides creative ways of analyzing the genetic ancestry of Finland


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Commercially available gene tests that shed light on individual’s origins are popular. They provide an estimate of the geographic regions where one’s ancestors come from. To arrive at such an estimate, the genetic information of an individual is compared to information pertaining to reference groups collected from around the world.
The findings now made by researchers from the University of Helsinki, Aalto University and the Finnish Institute for Health and Welfare make it possible, for the first time, to make similar comparisons within Finland.
The results of a new study made it possible to follow the traces of 20th century events in our genes and assess the effect of migration on the genetic mixing of the population. For example, it was possible to trace the migration of the evacuees from Finnish Karelia all across Finland on an annual level by exploring the share of the Karelian ancestry among the newborns of a given region. ....

Uusimaa Region , Varsinais Suomi , Southwest Finland , Eteläuomen Läi , Ostrobothnia Region , University Of Helsinki , Finnish Institute For Health , Associate Professor , Matti Pirinen , Finnish Institute , Sini Kerminen , Molecular Medicine Finland , Soviet Union , ஊசிமா பகுதி , தென்மேற்கு பின்லாந்து , ஒஸ்திரோபோடஞிய பகுதி , பல்கலைக்கழகம் ஆஃப் ஹெல்சின்கி , பின்னிஷ் நிறுவனம் க்கு ஆரோக்கியம் , இணை ப்ரொஃபெஸர் , பின்னிஷ் நிறுவனம் , மூலக்கூறு மருந்து பின்லாந்து , சோவியத் தொழிற்சங்கம் ,