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Light-controlled on/off switch helps control biological clock in cultured cells, explanted tissue


Light-controlled on/off switch helps control biological clock in cultured cells, explanted tissue
The biological clock is present in almost all cells of an organism. As more and more evidence emerges that clocks in certain organs could be out of sync, there is a need to investigate and reset these clocks locally. Scientists from the Netherlands and Japan introduced a light-controlled on/off switch to a kinase inhibitor, which affects clock function. This gives them control of the biological clock in cultured cells and explanted tissue. They published their results on 26 May in
Nature Communications.
Life on Earth has evolved under a 24-hour cycle; of light and dark, hot and cold. As a result, our cells are synchronized to these 24-hour oscillations, says Wiktor Szymanski, Professor of Radiological Chemistry at the University Medical Center Groningen. Our circadian clock is regulated by a central controller in the suprachiasmatic nucleus, a region in the brain direct ....

Tsuyoshi Hirota , Ben Feringa , Wiktor Szymanski , Emily Henderson , Molecules At Nagoya University , Institute Of Transformative Bio , Nature Communications , Nagoya University , University Medical Center Groningen , University Of Groningen , Tour De , Radiological Chemistry , University Medical Center , Study First Author , Phd Student , Transformative Bio Molecules , எமிலி ஹென்டர்சன் , மூலக்கூறுகள் இல் நாகோயா பல்கலைக்கழகம் , நிறுவனம் ஆஃப் உருமாறும் உயிர் , இயற்கை தகவல்தொடர்புகள் , நாகோயா பல்கலைக்கழகம் , பல்கலைக்கழகம் மருத்துவ மையம் க்ராநிகந் , பல்கலைக்கழகம் ஆஃப் க்ராநிகந் , சுற்றுப்பயணம் டி , பல்கலைக்கழகம் மருத்துவ மையம் , படிப்பு முதல் நூலாசிரியர் ,

Resetting the biological clock by flipping a switch


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IMAGE: Reversible modulation of the circadian clock using chronophotopharmacology. Using light to interconvert two isomers of a photo-responsive small molecule, it is possible to pace cellular time. While irradiation with violet.
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Credit: Issey Takahashi
The biological clock is present in almost all cells of an organism. As more and more evidence emerges that clocks in certain organs could be out of sync, there is a need to investigate and reset these clocks locally. Scientists from the Netherlands and Japan introduced a light-controlled on/off switch to a kinase inhibitor, which affects clock function. This gives them control of the biological clock in cultured cells and explanted tissue. They published their results on 26 May in ....

Tsuyoshi Hirota , Ben Feringa , Wiktor Szymanski , Molecules At Nagoya University , Institute Of Transformative Bio , Nature Communications , Nagoya University , University Medical Center Groningen , University Of Groningen , Tour De , Radiological Chemistry , University Medical Center , Transformative Bio Molecules , Molecular Biology , Medicine Health , Metabolism Metabolic Diseases , Circadian Rhythm , Leep Sleep Disorders , Pharmaceutical Chemistry , மூலக்கூறுகள் இல் நாகோயா பல்கலைக்கழகம் , நிறுவனம் ஆஃப் உருமாறும் உயிர் , இயற்கை தகவல்தொடர்புகள் , நாகோயா பல்கலைக்கழகம் , பல்கலைக்கழகம் மருத்துவ மையம் க்ராநிகந் , பல்கலைக்கழகம் ஆஃப் க்ராநிகந் , சுற்றுப்பயணம் டி ,