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Like night and day: Animal studies may not translate to humans without time considerations


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IMAGE: In a recent survey of published animal studies, Randy Nelson chair of the WVU Department of Neuroscience and director of basic science research for the Rockefeller Neuroscience Institute .
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Credit: WVU Photo/Jennifer Shephard
MORGANTOWN, W.Va. Imagine being woken up at 3 a.m. to navigate a corn maze, memorize 20 items on a shopping list or pass your driver s test.
According to a new analysis out of West Virginia University, that s often what it s like to be a rodent in a biomedical study. Mice and rats, which make up the vast majority of animal models, are nocturnal. Yet a survey of animal studies across eight behavioral neuroscience domains showed that most behavioral testing is conducted during the day, when the rodents would normally be at rest. ....

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Artificial intelligence predicts brain age from EEG signals recorded during sleep studies


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DARIEN, IL - A study shows that a deep neural network model can accurately predict the brain age of healthy patients based on electroencephalogram data recorded during an overnight sleep study, and EEG-predicted brain age indices display unique characteristics within populations with different diseases.
The study found that the model predicted age with a mean absolute error of only 4.6 years. There was a statistically significant relationship between the Absolute Brain Age Index and: epilepsy and seizure disorders, stroke, elevated markers of sleep-disordered breathing (i.e., apnea-hypopnea index and arousal index), and low sleep efficiency. The study also found that patients with diabetes, depression, severe excessive daytime sleepiness, hypertension, and/or memory and concentration problems showed, on average, an elevated Brain Age Index compared with the healthy population sample. ....

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