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New Cell Atlas Revolutionizes Biomedical Research

New Cell Atlas Revolutionizes Biomedical Research
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Paolo Parini , Lu Pan , Xuexin Li , Karolinska Institutet , Paola Paci , Zehuan Liao , Volker Lauschke , Roman Tremmel , Ingemar Ernberg , Bradleya Maron , Joseph Loscalzo , Volkerm Lauschke , Sundararaman Rengarajan , Ki Network Medicine Global Alliance , Department Of Medical Biochemistry , China Medical University , Institute Of Environmental Medicine , Department Of Physiology , Single Cell Atlas Consortium , Single Cell Atlas , Environmental Medicine , Medical Biochemistry , Medicine Global Alliance , Coauthor Volker Lauschke , Cell Atlas , Nguan Soon Tan ,

A novel antidiuretic hormone governs tumour-induced renal dysfunction

Maintenance of renal function and fluid transport are essential for vertebrates and invertebrates to adapt to physiological and pathological challenges. Human patients with malignant tumours frequently develop detrimental renal dysfunction and oliguria, and previous studies suggest the involvement of chemotherapeutic toxicity and tumour-associated inflammation1,2. However, how tumours might directly modulate renal functions remains largely unclear. Here, using conserved tumour models in Drosophila melanogaster3, we characterized isoform F of ion transport peptide (ITPF) as a fly antidiuretic hormone that is secreted by a subset of yki3SA gut tumour cells, impairs renal function and causes severe abdomen bloating and fluid accumulation. Mechanistically, tumour-derived ITPF targets the G-protein-coupled receptor TkR99D in stellate cells of Malpighian tubules—an excretory organ that is equivalent to renal tubules4—to activate nitric oxide synthase–cGMP signalling and inh ....

Al Dhaheri , Cell Biol , Cachexia Sarcopenia Muscle , Drosophila Malpighian , Cell Differ , Cell Atlas , Drosophilag Protein Coupled , Cell Rep , Model Mech ,

Vast diversity of human brain cell types revealed in trove of new datasets

The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function. ....

Salt Lake City , United States , San Francisco , University Of Utah , Joshua Sanes , Ed Lein , Tomasz Nowakowski , Andrea Beckel Mitchener , Trygve Bakken , Allen Institute For Brain Science , University Of Maryland School Medicine , University Of California , Harvard University , Initiative Cell Census Network , Us National Institutes Of Health , Initiative Cell Atlas Network , Allen Institute For Brain Science In Seattle , Allen Institute , Science Advances , Science Translational , Cell Census Network , Brain Science , Jason Shepherd , Human Gene Project , Cell Atlas , Seth Ament ,

Blue Brain Project Atlas Uncovers Neuron Types

Blue Brain Project Atlas Uncovers Neuron Types
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Atlas Bbcav , Yann Roussel , Dimitri Rodarie , Henry Markram , Daniel Keller , Allen Institute , Allen Institute For Brain Science , Brain Project , Blue Brain , Cell Atlas , Blue Brain Founder , Professor Henry , Blue Brain Project , Brain Science , Blue Brain Cell Atlas , Molecular Systems ,

Scientists create cell atlas of developing human lung

A research team has created a spatiotemporal cell atlas of the developing human lung, identifying 144 cell states in early life stages and their interactions. ....

United Kingdom , Kerstin Meyer , Sarah Teichmann , University Of Cambridge , Gordone Institute , European Bioinformatics Institute , Wellcome Sanger Institute , Bioinformatics Institute , Human Cell Atlas , Developmental Lung Cell Atlas , Lung Cell Atlas , Cell Biology , Lung Cells , Lung Cell Atlas , Cell Atlas , Human Cell Atlas Initiative , Wellcome Sanger Institute , European Bioinformatics Institute , Mbl Ebi , University Of Cambridge , Single Cell Sequencing , Respiratory System , Developmental Lung Cell Atlas , Lung Development , Single Cell Technologies ,