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Accurate and Fast Deep Learning Dose Prediction for a Preclinical Micr by Florian Mentzel, Jason Paino et al

Microbeam radiation therapy (MRT) utilizes coplanar synchrotron radiation beamlets and is a proposed treatment approach for several tumor diagnoses that currently have poor clinical treatment outcomes, such as gliosarcomas. Monte Carlo (MC) simulations are one of the most used methods at the Imaging and Medical Beamline, Australian Synchrotron to calculate the dose in MRT preclinical studies. The steep dose gradients associated with the 50 (Formula presented.) m-wide coplanar beamlets present a significant challenge for precise MC simulation of the dose deposition of an MRT irradiation treatment field in a short time frame. The long computation times inhibit the ability to perform dose optimization in treatment planning or apply online image-adaptive radiotherapy techniques to MRT. Much research has been conducted on fast dose estimation methods for clinically available treatments. However, such methods, including GPU Monte Carlo implementations and machine learning (ML) models, are un

Monte carloMedical beamlineAustralian synchrotronDeep learningLose predictionMicrobeam radiation therapyMonte carlo simulationPreclinical study

Evaluation of silicon strip detectors in transmission mode for online by Jeremy Davis, Andrew Dipuglia et al

Successful transition of synchrotron-based microbeam radiation therapy (MRT) from pre-clinical animal studies to human trials is dependent upon ensuring that there are sufficient and adequate measures in place for quality assurance purposes. Transmission detectors provide researchers and clinicians with a real-time quality assurance and beam-monitoring instrument to ensure safe and accurate dose delivery. In this work, the effect of transmission detectors of different thicknesses (10 and 375 μm) upon the photon energy spectra and dose deposition of spatially fractionated synchrotron radiation is quantified experimentally and by means of a dedicated Geant4 simulation study. The simulation and experimental results confirm that the presence of the 375 μm thick transmission detector results in an approximately 1-6% decrease in broad-beam and microbeam peak dose. The capability to account for the reduction in dose and change to the peak-to-valley dose ratio justifies the use of transm

Beam monitoringMicrobeam radiation therapyEal time dosimetryRansmission detectors

Incorporating clinical imaging into the delivery of microbeam radiatio by Jason Paino, Micah Barnes et al

Synchrotron microbeam radiation therapy is a promising pre-clinical radiation treatment modality; however, it comes with many technical challenges. This study describes the image guidance protocol used for Australia’s first long-term pre-clinical MRT treatment of rats bearing 9L gliosarcoma tumours. The protocol utilises existing infrastructure available at the Australian Synchrotron and the adjoining Monash Biomedical Imaging facility. The protocol is designed and optimised to treat small animals utilising high-resolution clinical CT for patient specific tumour identification, coupled with conventional radiography, using the recently developed SYNCMRT program for image guidance. Dosimetry performed in small animal phantoms shows patient dose is comparable to standard clinical doses, with a CT associated dose of less than 1.39 cGy and a planar radiograh dose of less than 0.03 cGy. Experimental validation of alignment accuracy with radiographic film demonstrates end to end accuracy of

South australiaAustralian synchrotronMonash biomedical imagingImage guidanceN vivoMicrobeam radiation therapy

Towards high spatial resolution tissue-equivalent dosimetry for microb by Jessie A Posar, Matthew Large et al

Spatially fractionated ultra-high-dose-rate beams used during microbeam radiation therapy (MRT) have been shown to increase the differential response between normal and tumour tissue. Quality assurance of MRT requires a dosimeter that possesses tissue equivalence, high radiation tolerance and spatial resolution. This is currently an unsolved challenge. This work explored the use of a 500nm thick organic semiconductor for MRT dosimetry on the Imaging and Medical Beamline at the Australian Synchrotron. Three beam filters were used to irradiate the device with peak energies of 48, 76 and 88keV with respective dose rates of 3668, 500 and 209Gys-1. The response of the device stabilized to 30% efficiency after an irradiation dose of 30kGy, with a 0.5% variation at doses of 35kGy and higher. The calibration factor after pre-irradiation was determined to be 1.02±0.005μGy per count across all three X-ray energy spectra, demonstrating the unique advantage of using tissue-equivalent materials f

Medical beamlineMicrobeam radiation therapyOrganic semiconductorsRadiation damageSynchrotron radiation

Microbeam Radiation Therapy: Development of Instrumentation and Softwa by Matthew John Cameron

Microbeam Radiation Therapy: Development of Instrumentation and Softwa by Matthew John Cameron
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Microbeam radiation therapyDose volume effect