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Study reveals genetic signature of colibactin implicated in the development colorectal cancers Escherichia coli bacteria are constitutive members of the human gut microbiota. However, some strains produce a genotoxin called colibactin, which is implicated in the development of colorectal cancer. While it has been shown that colibactin leaves very specific changes in the DNA of host cells that can be detected in colorectal cancer cells, such cancers take many years to develop, leaving the actual process by which a normal cell becomes cancerous obscure. The group of Thomas F. Meyer at the Max Planck Institute for Infection Biology in Berlin together with their collaborators have now been able to catch colibactin in the act of inducing genetic changes that are characteristic of colorectal cancer cells and cause a transformed phenotype - after only a few hours of infection.

Thomasf meyerAmina iftekharMichael sigalEmily hendersonUniversity hospitalMax planck institute for infection biologyMax planck instituteInfection biologyE coliColorectal cancerGrowth factorStem cellsஅமினா இப்தெகர்எமிலி ஹென்டர்சன்பல்கலைக்கழகம் மருத்துவமனைதொற்று உயிரியல்