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NIR Laser Responsive Nanoparticle for OC combination therapy


2S
3 modified by oleic acid and PLGA-PEG-FA were obtained from Xi’an Ruixi Biological Technology Co., Ltd. (China). Perfluoropentane (PFP) was obtained from Strem Chemicals, Inc. (America). Cell Counting Kit-8 (CCK-8) was obtained from Dojindo (Japan). The 2-(4-Amidinophenyl)-6-indolecarbamidinedihydrochloride (DAPI) and Trypsin-EDTA solution (0.25% trypsin) were obtained from Beyotime Technology. Dichloromethane (CHCl
2) and isopropyl alcohol were obtained from Chongqing Chuan Dong Chemical Co., Ltd. (China). Poly (vinyl alcohol) (PVA), 1,1′-dioctadecyl-3,3,3′,3′- tetramethylindotricarbocyanine iodide (DiR) and Dialysis membrane (10000–12000Da) were obtained from Sigma-Aldrich Chemical Co., Ltd. (MW: 25000, America). McCoy’s 5A was obtained from Procell Life Science&Technology Co., Ltd. ....

Yu Xin , South Korea , Biocompatible Theranostic Nanoagent , Yangz Photothermal , Carbohydr Polym , Mohammadi Gazestani , Jiangx Microfluidics , Emamgholizadeh Minaei , Animal Ethics Committee Of Chongqing Medical University , Chodaczekg Nanoemulsion Structural Design In Co , Laboratory Animals Of Chongqing Medical University , Drug Administration , Yangh Co , Postgraduate Research , Cell Counting , End Labeling , Laboratory Animals , Chongqing Medical University , Animal Ethics Committee , Chongqing Medical , National Natural Science Foundation , China Youth Science Foundation Project , Medical Science Cultivation Fund , First Affiliated Hospital , Chongqing Postgraduate Research , Innovation Project ,

Diagnosis and precise nanocarrier-bowel disease therapy


82 and lipid nanoparticles
74 have been developed and used in cancer imaging and diagnosis. During traditional clinical CT imaging, iodinated small molecules and barium sulfate suspensions are usually used as contrast agents,
121,122 but they are not ideal for imaging IBD due to their nonspecificity. Furthermore, when administered orally, these suspensions are nonspecifically distributed throughout the GIT, thus interfering with diagnosis and leading to accumulative radiation exposure in IBD patients.
123 Therefore, the CT contrast agent must not only be stable in the GIT microenvironment but also must be specifically enriched in the diseased parts of the intestine to better detect disease.
Based on the microenvironmental characteristics of the GIT and the design strategy of orally administered DDSs for IBD therapy, the application of nanoparticles may create ideas for the CT imaging in IBD. Naha et al designed and synthesized nanocontrast agents that can be used i ....

Saudi Arabia , Sri Lanka , Nano Lett , Panchagnular Peroral , Liuf Immunomodulation , Acta Biomater , Jons Biotinylated , Vllasaliud Ascorbyl , Daneses Biosimilar , Carbohydr Polym , Pan Stanford , Gastroenterol Hepatol , Jpharm Biopharm , Traversog Nanoparticulate , Macromol Biosci , Scandj Gastroenterol , National Natural Science Foundation Of China , Springer International Publishing , National Natural Science Foundation , Innovative Research Team , Rev Gastroenterol , Inflammatory Bowel , Shiht Y , Opin Drug , Mater Chem , Dufresnem H ,