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'Unheard of in structural biology': New enzyme models reveal disease insights

'Unheard of in structural biology': New enzyme models reveal disease insights
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Ziqi Feng , Fangkun Luan , Linghang Peng , Ian Wilson , Xueyong Zhu , Amanda Gavin , Jenny Tran , David Nemazee , Jeanne Matteson , Department Of Integrative Structural , Scripps Research , Computational Biology At Scripps Research , Department Of Immunology , Meng Yuan , Integrative Structural , Computational Biology , Deli Huang ,

Versatile coronavirus antibody may be starting point for broader-acting vaccines


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LA JOLLA, CA Even before the COVID-19 pandemic, most people in the United States already had been sick with a coronavirus, albeit a far less dangerous one. That s because at least four coronaviruses in the same general family as SARS-CoV-2 cause the benign yet annoying illness known as the common cold.
In a new study that appears in
Nature Communications, scientists from Scripps Research investigated how the immune system s previous exposure to cold-causing coronaviruses impact immune response to COVID-19. In doing so, they discovered one cross-reactive coronavirus antibody that s triggered during a COVID-19 infection.
The findings will help in the pursuit of a vaccine or antibody treatment that works against most or all coronaviruses, says senior author Raiees Andrabi, PhD, an investigator in the Department of Immunology and Microbiology. ....

United States , Nathan Beutler , Thomas Rogers , Davey Smith , James Ricketts , James Voss , David Nemazee , Mara Parren , Sean Callaghan , Linghang Peng , Linlin Yang , Andrew Ward , Jon Cassell , Raiees Andrabi , Jonathan Torres , Dennis Burton , Fabio Anzanello , Sirena Vargas , Caroline Ignacio , Nature Communications , Antibody Center , Jamesb Pendleton Charitable , Melinda Gates Foundation , Scripps Research , Mary Tu Foundation , Department Of Immunology ,