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Implausible algorithm output in UK liver transplantation allocation scheme: importance of transparency

Algorithm-based allocation of resource-limited health-care interventions is growing;
however, concerns over transparency and bias have restricted its use.1 Transparent
algorithms can be readily explained, allowing patients and clinicians to clearly understand
the basis for decision making.2 In 2018, the Transplant Benefit Score (TBS) was introduced
to allocate deceased donor livers to patients with chronic liver disease and primary
liver cancer (hepatocellular carcinoma) on a national basis. Patients might also undergo
transplantation for acute liver failure, although these patients are allocated organs
via a different process. ....

United States , United Kingdom , City Of , Kelsey Pearson , Elisa Norman , Data Team At Edinburgh Transplant Centre , Elsevier Ltd , Liver Dis , Data Team , Edinburgh Transplant Centre ,

Hepatitis B

Hepatitis B virus (HBV) infection is a major public health problem, with an estimated
296 million people chronically infected and 820 000 deaths worldwide in 2019. Diagnosis
of HBV infection requires serological testing for HBsAg and for acute infection additional
testing for IgM hepatitis B core antibody (IgM anti-HBc, for the window period when
neither HBsAg nor anti-HBs is detected). Assessment of HBV replication status to guide
treatment decisions involves testing for HBV DNA, whereas assessment of liver disease
activity and staging is mainly based on aminotransferases, platelet count, and elastography. ....

United States , United Kingdom , South Korea , Clin Gastroenterol , J Gastroenterol Hepatol , Clin Gastroenterol Hepatol , Natn Engl , Ann Gastroenterol , J Antimicrob Chemother , Van Damme , Gastroenterol Hepatol , Centers For Disease , Dynavax Technologies Corporation , Study Group , World Health Organization , Vaccines Inc , European Consensus Group On Hepatitisb Immunity , European Medicines Agency , Global Burden , Disease Study , Englj Med , Infect Dis , Health Organization , Transl Med , Liver Dis , North America ,