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Researchers speed identification of DNA regions that regulate gene expression

Date Time
Researchers speed identification of DNA regions that regulate gene expression
Corresponding author Yong Cheng, Ph.D., of the St. Jude Departments of Hematology and Computational Biology, helped develop a highly efficient method in identifying the genetic switches that regulate gene expression.
St. Jude Children’s Research Hospital scientists have developed an integrated, high-throughput system to better understand and possibly manipulate gene expression for treatment of disorders such as sickle cell disease and beta thalassemia. The research appears today in the journal Nature Genetics.
Researchers used the system to identify dozens of DNA regulatory elements that act together to orchestrate the switch from fetal to adult hemoglobin expression. The method can also be used to study other diseases that involve gene regulation. ....

Peng Xu , Jingjing Chen , Qian Qi , Lance Palmer , Ruiqiong Wu , Akshay Sharma , Ross Hardison , Ruopeng Feng , Jingjing Zhang , Li Cheng , Tiffany Yee , Yichao Li , Mitchell Weiss , Jude Children Research Hospital , National Institutes Of Health , Pennsylvania State University , Jude Department Of Hematology , Computational Biology , Jude Children , Research Hospital , Jude Departments , Jude Sickle Cell Genome Project , Pennsylvania State , National Institutes , பெங் ஐயூ , லான்ஸ் பாமர் ,

Clinical trial of targeted therapy for pediatric Hodgkin lymphoma shows excellent outcomes

Clinical trial of targeted therapy for pediatric Hodgkin lymphoma shows excellent outcomes
news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.

United States , Dana Farber Cancer Institute , Matthew Krasin , Monika Metzger , Melissa Hudson , Hodgkin Reed Sternberg , Emily Henderson , Maine Children Cancer Program , Jude Children Research Hospital , Jude Department Of Radiation Oncology , Jude Cancer Survivorship Division , Stanford University School Of Medicine , Jude Children , Research Hospital , Stanford University School , Massachusetts General Hospital , Maine Children , Cancer Program , Jude Departments , Global Pediatric , Jude Department , ஒன்றுபட்டது மாநிலங்களில் , டானா ஃபார்‌பர் புற்றுநோய் நிறுவனம் , மோனிகா மெதஜ்கேர் , மெலிசா ஹட்சன் , ஹாட்ஜ்கின் நாணல் ஸ்டென்பெர்க் ,

Excellent outcomes reported for first targeted therapy for pediatric Hodgkin lymphoma

Excellent outcomes reported for first targeted therapy for pediatric Hodgkin lymphoma
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

United States , Dana Farber Cancer Institute , Belinda Mandrell , Susan Hiniker , Alison Friedmann , John Lucas Jr , Sandra Luna Fineman , Chen Li , Matthew Ehrhardt , Matthew Krasin , Monika Metzger , Nickhill Bhakta , Amy Billett , Melissa Hudson , Hodgkin Reed Sternberg , Zhaohua Lu , Barry Shulkin , Jamie Flerlage , Eric Larson , Nemours Alfredi Dupont , Torunn Yock , Sarah Donaldson , National Cancer Institute , Jude Children Research Hospital , Jude Department Of Radiation Oncology , Stanford University School Of Medicine ,

Targeted therapy achieves excellent outcomes, reduces side effects in high-risk Hodgkin lymphoma

Targeted therapy achieves excellent outcomes, reduces side effects in high-risk Hodgkin lymphoma
news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.

United States , Dana Farber Cancer Institute , Matthew Krasin , Monika Metzger , Melissa Hudson , Hodgkin Reed Sternberg , Emily Henderson , Maine Children Cancer Program , Jude Children Research Hospital , Study Co , Jude Department Of Radiation Oncology , Jude Cancer Survivorship Division , Stanford University School Of Medicine , Jude Children , Research Hospital , Stanford University School , Massachusetts General Hospital , Maine Children , Cancer Program , Jude Departments , Global Pediatric , Study Co Senior Author , Jude Department , ஒன்றுபட்டது மாநிலங்களில் , டானா ஃபார்‌பர் புற்றுநோய் நிறுவனம் , மோனிகா மெதஜ்கேர் ,

Excellent outcomes reported for first targeted frontline therapy for high-risk pediatric Hodgkin lymphoma

Date Time
Excellent outcomes reported for first targeted frontline therapy for high-risk pediatric Hodgkin lymphoma
(From left) First and corresponding author Monika Metzger, M.D., Departments of Oncology and Global Pediatric Medicine; co- senior author Matthew Krasin, M.D., Department of Radiation Oncology; and co-senior author Melissa Hudson, M.D., Cancer Survivorship Division director.
Scientists are reporting results of the first frontline clinical trial to use targeted therapy to treat high-risk pediatric Hodgkin lymphoma. The study showed that the addition of brentuximab vedotin achieved excellent outcomes, reduced side effects, and allowed for reduced radiation exposures.
The study was the result of work by a multi-site consortium dedicated to pediatric Hodgkin-lymphoma. Collaborating institutions include St. Jude Children’s Research Hospital, Stanford University School of Medicine, Dana-Farber Cancer Institute, Massachusetts General Hospital, Maine Childr ....

United States , Dana Farber Cancer Institute , Belinda Mandrell , Susan Hiniker , Alison Friedmann , John Lucas Jr , Sandra Luna Fineman , Chen Li , Matthew Ehrhardt , Matthew Krasin , Monika Metzger , Nickhill Bhakta , Amy Billett , Melissa Hudson , Hodgkin Reed Sternberg , Zhaohua Lu , Barry Shulkin , Jamie Flerlage , Eric Larson , Nemours Alfredi Dupont , Torunn Yock , Sarah Donaldson , National Cancer Institute , Jude Children Research Hospital , Judecancer Survivorship Division , Stanford University School Of Medicine ,