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Scientists develop new organoid model to stud

<p>Researchers from the Organoid group have developed a new organoid model that can be used to study the thymus. The organoids, derived from mouse thymus tissue, specifically model thymic epithelial cells (TECs). These cells are responsible for training the T cells of the immune system to properly respond to pathogens. It is the first laboratory model that enables long-term culture of TECs, which presents new opportunities to study their function. Ultimately, this could also bring new insights into the treatment of patients with impaired thymus function. The study was published in Cell Reports on 27 March 2024.</p>
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Harry Begthel , Hong Gyun Lee , Hans Clevers , Jeroen Korving , Sam Willemsen , Developmentat Roche , Amanda Andersson Rolf , Wisma Eka Yanti , Hubrecht Institute , Pharma Research , Method Of Research , Royal Netherlands Academy Of Arts , Hubrecht Institute For Developmental Biology , Utrecht University , Early Development , Stem Cell Research , European Molecular Biology Laboratory , Head Of Pharma Research , Cell Reports , Sangho Lim , Developmental Biology , Molecular Genetics , Royal Netherlands Academy , Utrecht Science , Early Developmentat Roche ,

Researchers Create First Model of Human Conjunctiva in Dish

Researchers Create First Model of Human Conjunctiva in Dish
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Harry Begthel , Morm Dickman , Makoto Yawata , Bartl Haagmans , Martm Lamers , Saskiam Imhoff , Peterj Peters , Rachel Kalmann , Jeroen Korving , Wei Wu , Marie Bannier , Hans Clevers , Vanessals Lapointe , Nobuyo Yawata , Amir Giladi , Ziliang Ma , Hubrecht Institute , Cell Stem , Conjunctiva Organoids , Study Ocular Surface Homeostasis , Marie Bannier H ,

Promising New Therapy for Pulmonary Neuroendocrine Tumors

Promising New Therapy for Pulmonary Neuroendocrine Tumors
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Nielsfm Kok , Sylvie Lantuejoul Sridevi Jaksani , Lodewijkaa Brosens , Antonellafm Dost , Anne Marie Dingemans , Margot Tesselaar , Catherine Voegele , Talya Dayton , Nicolas Alcala , Wenzelm Hackeng , Koenj Hartemink , Lisa Hillen , Houkem Klomp , Harry Begthel , Sonja Levi , Kris Samsom , Gerlofd Valk , Wieneke Buikhuisen , Lise Mangiante , Talyal Dayton , Veerle Geurts , Jules Derks , Laura Moonen , Joep Beumer , Lynnette Fern , Alexandra Sexton Oates ,

First patient-derived organoid model for cervical cancer

First patient-derived organoid model for cervical cancer
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Onnow Kranenburg , Hans Clevers , Trudygn Jonges , Ruben Van Boxtel , Jose Espejo Valle Inclan , Sebastiaan Veersema , Milouhh Smits , Jeroen Korving , Natalie Proost , Harry Begthel , Hila Wardak , Rurika Oka , Ronaldp Zweemer , Hans Clevers Hubrecht Institute , Molecular Genetics At Utrecht University , Netherlands Cancer Institute , Hubrecht Institute , Cell Stem , Netherlands Cancer , Pediatric Oncology , Molecular Genetics , Utrecht University , ரூபன் வேன் போஸ்ட்டல் , மூலக்கூறு ஜெநெடிக்ஸ் இல் அட்ரெக்ட் பல்கலைக்கழகம் , நெதர்லாந்து புற்றுநோய் நிறுவனம் , செல் தண்டு ,

Crying human tear glands grown in the lab

Credit: Marie Bannier-Hélaouët, copyright Hubrecht Institute
Researchers from the lab of Hans Clevers (Hubrecht Institute) and the UMC Utrecht used organoid technology to grow miniature human tear glands that actually cry. The organoids serve as a model to study how certain cells in the human tear gland produce tears or fail to do so. Scientists everywhere can use the model to identify new treatment options for patients with tear gland disorders, such as dry eye disease. Hopefully in the future, the organoids can even be transplanted into patients with non-functioning tear glands. The results will be published in ....

Helmuth Gehart , Hans Clevers , Marie Bannier , Saskiam Imhof , Marc Trani Bustos , Jeroen Korving , Rachel Kalmann , Harry Begthel , Hans Clevers Hubrecht Institute , Molecular Genetics At Utrecht University , Hubrecht Institute , Cell Stem , Yorick Post , Stem Cell , Pediatric Oncology , Molecular Genetics , Utrecht University , Cell Biology , Medicine Health , மார்க் திரணி பஸ்‌டோஸ் , மூலக்கூறு ஜெநெடிக்ஸ் இல் அட்ரெக்ட் பல்கலைக்கழகம் , செல் தண்டு , தண்டு செல் , குழந்தை புற்றுநோயியல் , மூலக்கூறு ஜெநெடிக்ஸ் , அட்ரெக்ட் பல்கலைக்கழகம் ,