<p>Researchers from the Organoid group have developed a new organoid model that can be used to study the thymus. The organoids, derived from mouse thymus tissue, specifically model thymic epithelial cells (TECs). These cells are responsible for training the T cells of the immune system to properly respond to pathogens. It is the first laboratory model that enables long-term culture of TECs, which presents new opportunities to study their function. Ultimately, this could also bring new insights into the treatment of patients with impaired thymus function. The study was published in Cell Reports on 27 March 2024.</p>
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Rare Cell Types Identified in Gastrointestinal Tract
Microbiome in human gastrointestinal tract [ Marcin Klapczynski/Getty Images]
March 10, 2021
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The gastrointestinal tract (GI) is the pathway from your mouth to your esophagus, stomach, and small and large intestines. In the GI tract, nutrients and water from food are absorbed to help keep your body healthy. Using single-cell RNA sequencing, researchers from the Hubrecht Institute report they studied the cellular composition of the upper gastrointestinal tract and have identified and characterized rare cell types.
Cell Reports and led by Hans Clever, PhD, principal investigator at the Hubrecht Institute for Developmental Biology and Stem Cell Research.