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Familial Hypercholesterolemia Variants Linked to Coronary Heart Disease Risk

Even when cholesterol levels were only moderately elevated, familial hypercholesterolemia variants were associated with greater cardiovascular risk. ....

Yiyi Zhang , Cardiovascular Health Study , Columbia University Yiyi Zhang , Us Centers For Disease , Artery Risk Development In Young Adults , Columbia University Medical Center , Columbia University , Columbia University Medical , Disease Control , Atherosclerosis Risk , Coronary Artery Risk Development , Young Adults , Framingham Heart Study Offspring , Jackson Heart Study , Multi Ethnic Study ,

Gene-Specific CHIP Subtype Significantly Associated with HFpEF Risk

Across two large, diverse cohorts, TET2 CHIP was associated with a more than 2-fold higher risk of incident HF with preserved ejection fraction. ....

United States , Michaelc Honigberg , Cardiovascular Research Center , Women Health Initiative , Massachusetts General Hospital , Genomic Medicine , Massachusetts General , Jackson Heart Study , Health Initiative ,

Familial Hypercholesterolemia May Double Coronary Heart Disease Risk in Moderately Elevated LDL-C

However, the association between familial hypercholesterolemia variants and coronary heart disease slightly weakened after adjusting for baseline low-density lipoprotein cholesterol (LDL-C) level and became statistically insignificant after adjusting for cumulative past LDL-C exposure. ....

Artery Risk Development In Young Adults , Cardiovascular Health Study , Atherosclerosis Risk , Coronary Artery Risk Development , Young Adults , Framingham Heart Study Offspring , Jackson Heart Study , Multi Ethnic Study , Familial Hypercholesterolemia , Coronary Heart Disease , Ldl C , Low Density Lipoprotein Cholesterol , Jama Cardiology ,

TET2 CHIP an Independent Risk Factor for HFpEF, Study Says

Researchers found TET2 clonal hematopoiesis of indeterminate potential (CHIP) to be an independent risk factor associated with incident heart failure with preserved ejection fraction (HFpEF). ....

United States , Women Health Initiative , Jackson Heart Study , Health Initiative , African American , Heart Failure , Jama Network Open ,

How one health study, inspired by FDR's death, changed life in America forever

The Framingham Heart Study identified heart disease risk factors and changed Americans' health status. ....

Patrick Cemetery , United States , George Oconnor , Esther Monahan , Agnes Renzi Decenzo , Honghuang Lin , James Savage , Daniel Levy , William Monahan , Dariush Mozaffarian , Blood Institute , Boston University , National Heart , Dennison Manufacturing Company , Us Department Of Agriculture , Tufts University , University Of Massachusetts Chan Medical School , Friedman School Of Nutrition Science , Coronary Heart Disease Risk Score , Georgeo Connor , Framingham Heart , Mable Savage , Eden Street , Framingham Heart Study , Friedman School , Nutrition Science ,