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Gene-Specific CHIP Subtype Significantly Associated with HFpEF Risk

Across two large, diverse cohorts, TET2 CHIP was associated with a more than 2-fold higher risk of incident HF with preserved ejection fraction.

United statesMichaelc honigbergCardiovascular research centerWomen health initiativeMassachusetts general hospitalGenomic medicineMassachusetts generalJackson heart studyHealth initiative

Research Links Circulating Proteins to Pregnancy Hypertension Disorders

Research Links Circulating Proteins to Pregnancy Hypertension Disorders
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United statesBuu truongWhitney hornsbyMaddalena ardissinoStephen burgessMalissaj woodKathrynj grayMi jemma choPradeep natarajanMichaelc honigbergTajmara antoineJasond rohAmya sarmaQi yanZhi yuJamesl januzzi jr

Proteins Linked to Pregnancy Hypertensive Disorders Discovered

New insights into pregnancy hypertensive disorders reveal diverse pathways blood vessel regulation, inflammation, immunity involved in disease development.

United statesMichaelc honigbergBroad instituteMedicine at harvard medical schoolMassachusetts general hospitalHarvard medicalHypertension during pregnancyPregnancy complications

Researchers identify circulating proteins linked to preeclampsia and other hypertensive disorders of pregnancy

Researchers identify circulating proteins linked to preeclampsia and other hypertensive disorders of pregnancy
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United statesMichaelc honigbergMedicine at harvard medical schoolBroad instituteMassachusetts general hospitalHarvard medicalArt schuermansGenetic associations

MGH study identifies key proteins linked to pregnancy hypertension disorders

Preeclampsia and other hypertensive disorders of pregnancy-;which are characterized by high blood pressure with or without organ dysfunction during the second half of pregnancy-;carry considerable short- and long-term risks for both the mother and child. Treatment options (other than expedited delivery) remain limited.

United statesMi jemma choDarina postupakaJamesl januzzi jrJasond rohTajmara antoineAdams butterworthStephen burgessMalissaj woodQi yanPradeep natarajanMaddalena ardissinoWhitney hornsbyMichaelc honigbergEmilys lauZhi yu