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Light-Activated Drug Induces Sleep by Targeting Specific Brain Region

Novel light-sensitive drug induces sleep without genetic modification

The nucleus accumbens plays a pivotal role in motivational behavior and sleep regulation, modulated by adenosine A2A receptors (A2AR).

Study develops light-activated drug targeting receptors in the brain that induce sleep

Adenosine A2A receptors (A2AR) in the nucleus accumbens of the brain play an important role in regulating sleep and motivation, but until now, no drugs have been able to selectively modulate their function without affecting other organs or brain areas. In a recent study, a light-activated allosteric modulator of A2AR was developed and successfully used to remotely induce sleep by selective light irradiation of the nucleus accumbens in mice.

Japan's sleep-deprived employees embrace the workplace nap – DW – 10/06/2023

Government and experts warn that Japanese people are not getting enough good quality sleep, risking health issues, irritation and a loss of focus at work.

Japan's sleep-deprived employees embrace the workplace nap

Government and experts warn that Japanese people are not getting enough good quality sleep, risking health issues, irritation and a loss of focus at work. | Health