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Novel light-sensitive drug induces sleep without genetic modification

The nucleus accumbens plays a pivotal role in motivational behavior and sleep regulation, modulated by adenosine A2A receptors (A2AR). ....

Tsuyoshi Saitoh Tri , Michael Lazarus , University Of Tsukuba , International Institute For Integrative Sleep Medicine , Technology Agency , World Premier International Research Center Initiative , Scientific Research , Institute Of Medicine , Integrative Sleep , Professor Michael Lazarus , Associate Professor Tsuyoshi Saitoh , International Institute , Integrative Sleep Medicine , Japan Science ,

Study develops light-activated drug targeting receptors in the brain that induce sleep

Adenosine A2A receptors (A2AR) in the nucleus accumbens of the brain play an important role in regulating sleep and motivation, but until now, no drugs have been able to selectively modulate their function without affecting other organs or brain areas. In a recent study, a light-activated allosteric modulator of A2AR was developed and successfully used to remotely induce sleep by selective light irradiation of the nucleus accumbens in mice. ....

Koustav Roy , Tsuyoshi Saitoh Tri , Michael Lazarus , University Of Tsukuba , Institute Of Medicine , Nature Communications , International Institute For Integrative Sleep Medicine , Professor Michael Lazarus , Associate Professor Tsuyoshi Saitoh , International Institute , Integrative Sleep Medicine ,