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Scientists atSt. JudeChildren’s Research Hospital are working with colleagues in China to develop better therapy for childhood acute lymphoblastic leukemia (ALL). Results from a large phase 3 noninferiority clinical trial definitively showed that vincristine and dexamethasone pulses can be eliminated in patients with low-risk disease. The findings were published today in
The
Lancet Oncology.
Adding the chemotherapy vincristine plus a steroid (originally prednisone, and later dexamethasone) as pulse therapy for childhood ALL has been part of standard care since the 1970s. This is despite their being associated with neuropsychological side effects, neuropathy and other late effects. However, to date studies about the need for prolonged treatment with pulse therapy have been inconclusive. ....

Hong Kong , Hua Jiang , University Of Hong Kong , Hong Kong General , Hui Jiang , Hui Zhang , Jing Chen , Jingyan Tang , Aiguo Liu , Ju Gao , Yingchi Zhang , Wenyu Yang , Changda Liang , Minghua Yang , Kaili Pan , Runming Jin , Yongjun Fang , Chunfu Li , Yiping Zhu , Lirong Sun , Junj Yang , Jiaoyang Cai , Jie Yu , Xuedong Wu , Xiaowen Zhai , Ningling Wang ,

International collaboration helps refine treatment for childhood leukemia

International collaboration helps refine treatment for childhood leukemia
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Hong Kong , Hua Jiang , University Of Hong Kong , Hong Kong General , Hui Jiang , Hui Zhang , Jing Chen , Jingyan Tang , Aiguo Liu , Ju Gao , Yingchi Zhang , Wenyu Yang , Changda Liang , Minghua Yang , Kaili Pan , Runming Jin , Yongjun Fang , Chunfu Li , Yiping Zhu , Lirong Sun , Junj Yang , Jiaoyang Cai , Jie Yu , Xuedong Wu , Xiaowen Zhai , Ningling Wang ,