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<p>Researchers from the Organoid group have developed a new organoid model that can be used to study the thymus. The organoids, derived from mouse thymus tissue, specifically model thymic epithelial cells (TECs). These cells are responsible for training the T cells of the immune system to properly respond to pathogens. It is the first laboratory model that enables long-term culture of TECs, which presents new opportunities to study their function. Ultimately, this could also bring new insights into the treatment of patients with impaired thymus function. The study was published in Cell Reports on 27 March 2024.</p>

Harry begthelHong gyun leeHans cleversJeroen korvingSam willemsenDevelopmentat rocheAmanda andersson rolfWisma eka yantiHubrecht institutePharma researchMethod of researchRoyal netherlands academy of artsHubrecht institute for developmental biologyUtrecht universityEarly developmentStem cell research