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Rare Cell Types Identified in Gastrointestinal Tract
Microbiome in human gastrointestinal tract [ Marcin Klapczynski/Getty Images]
March 10, 2021
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The gastrointestinal tract (GI) is the pathway from your mouth to your esophagus, stomach, and small and large intestines. In the GI tract, nutrients and water from food are absorbed to help keep your body healthy. Using single-cell RNA sequencing, researchers from the Hubrecht Institute report they studied the cellular composition of the upper gastrointestinal tract and have identified and characterized rare cell types.
Cell Reports and led by Hans Clever, PhD, principal investigator at the Hubrecht Institute for Developmental Biology and Stem Cell Research.
Researchers identified and characterized rare cell types in the esophagus, stomach and upper part of the small intestine, using single cell RNA sequencing. They provide detailed gene expression analyses for all epithelial cells in these organs. Furthermore, they identified a rare cell type that is most likely responsible for the secretion of high volumes of water in humans, providing a link to gastrointestinal defects in patients with cystic fibrosis.