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Store Fat or Burn It? Targeting a Single Protein Flips the Switch

Store Fat or Burn It? Targeting a Single Protein Flips the Switch As obesity becomes a growing issue worldwide – nearly tripling over the last-half century – scientists are trying to gain a better understanding of the condition at the molecular level. Now, new research led by UC San Francisco scientists suggests that a single protein could play an outsized role in weight gain. As reported in  Nature Metabolism on Feb. 18, 2021, UCSF’s Davide Ruggero, PhD, and colleagues found that mice in which activity of a protein called eIF4E is diminished, either genetically or pharmaceutically, gain only half the weight of other mice, even if all the mice eat a high-fat diet.

Is this one protein responsible for weight gain?

Credit: UCSF As obesity becomes a growing issue worldwide  nearly tripling over the last-half century  scientists are trying to gain a better understanding of the condition at the molecular level. Now, new research led by UC San Francisco scientists suggests that a single protein could play an outsized role in weight gain. As reported in Nature Metabolism on Feb. 18, 2021, UCSF’s Davide Ruggero, Ph.D., and colleagues found that mice in which activity of a protein called eIF4E is diminished, either genetically or pharmaceutically, gain only half the weight of other mice, even if all the mice eat a high-fat diet.

Store fat or burn it? Targeting a single protein flips the switch

As obesity becomes a growing issue worldwide - nearly tripling over the last-half century - scientists are trying to gain a better understanding of the condition at the molecular level. Now, new research led by UC San Francisco scientists suggests that a single protein could play an outsize role in weight gain.

Store Fat or Burn It? Targeting a Single Protein Flips Switch

As obesity becomes a growing issue worldwide - nearly tripling over the last-half century - scientists are trying to gain a better understanding of the.

Store Fat or Burn It? Targeting a Single Protein Flips the Switch

Store Fat or Burn It? Targeting a Single Protein Flips the Switch
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