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Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.
AIDS virus-neutralizing antibody induction reciprocal to a PI3K gain-of-function disease elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.
Oral administration of fingolimod inhibits CD4+T lymphocyte recruitment and TNF-a-induced inflammation in a collagen-induced arthritis mouse model. Read more. ....
In the current study, DDR1 has been identified as a cancer-associated receptor tyrosine kinase that is highly expressed in several malignancies relative to normal tissues. 29 As an important receptor, DDR1 can bind all types of collagens and could influence their signalling upon collagen stimulation. 30 It has been reported that the phosphorylation of DDR1 could activate the WNT/β-catenin and AKT/mTOR signaling to drive cancer cell metastasis and progression. 31,32 We observed that pY792 DDR1, the active form of DDR1, was upregulated by COL5A2 overexpression in HCT116 and SW620 cells (Figure 4D). These observations indicate that COL5A2 expression upregulates WNT/β-catenin and PI3K/mTOR signaling via binding DDR1 with phosphorylation and activation of this receptor, which might contribute to CRC tumorigenesis or progression. ....