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Oral lipid nanoparticle drug shows promise for preventing colitis-associated cancer in mice

An oral lipid nanoparticle drug prevents tumor development in mice, suggesting this is a promising drug formulation for preventing colitis-associated cancer, according to a study led by researchers in the Institute for Biomedical Sciences at Georgia State University. ....

United States , Zahra Alghoul , Chunhua Yang , Danielle Ellis , Didier Merlin , Crohn Colitis Foundation , Department Of Chemistry At Georgia , Institute For Biomedical Sciences , National Institute Of Diabetes , Atlanta Veterans Affairs Medical Center , Department Of Veterans Affairs , Institute For Biomedical Sciences At Georgia , Biomedical Sciences , Georgia State , Regent Professor , Atlanta Veterans Affairs Medical , Dingpei Long , Colitis Foundation , Junsik Sung , National Institute , Kidney Diseases , National Institutes , Crohn 39s Disease , Dna Damage , Inflammatory Bowel Disease , Ulcerative Colitis ,

Study reveals how DNA damage caused by chromosomal instability increases cancer invasiveness

Chromosomal instability is a phenomenon characterized by rapid changes in the number and structure of chromosomes during cell division. ....

Comunidad Autonoma De Cataluna , Kaustuv Ghosh , Lara Barrio , Mariana Muzzopappa , Megan Craig , Elena Gaspar , European Union Horizon , Spanish Ministry Of Science , Growth Control , Marco Milan , Ana Elena Gaspar , Spanish Ministry , European Union , Dna Damage , Ell Death , Cell Division ,

Study reveals a complex interplay of genetic and epigenetic changes in Alzheimer's disease progression

Alzheimer's disease affects more than 6 million people in the United States, and there are very few FDA-approved treatments that can slow the progression of the disease. ....

United States , Vishnu Dileep , Benjamin James , Zhuyu Verna Peng , Manolis Kellis , Carles Boix , Danielle Ellis , Matheus Victor , Hansruedi Mathys , Li Huei Tsai , Xushen Xiong , Cure Alzheimer Foundation , Broad Institute , National Institutes Of Health , Artificial Intelligence Laboratory , Picower Institute For , Artificial Intelligence , Religious Orders , Aging Project , Carles Boix Phd , National Institutes , Cure Alzheimer , Lzheimer 39s Disease , Artificial Intelligence , Dna Damage , Ene Expression ,

Decoding the complexity of Alzheimer's disease | MIT News | Massachusetts Institute of Technology

Using more than 2 million cells from over 400 postmortem brain samples, MIT researchers performed the largest-scale analysis of the genomic, epigenomic, and transcriptomic changes that occur in every cell type in the brains of Alzheimer’s patients. ....

United States , Li Huei Tsai , Manolis Kellis , Matheus Victor , Hansruedi Mathys , Carles Boix , Zhuyu Verna Peng , Benjamin James , Xushen Xiong , Vishnu Dileep , Broad Institute , Picower Institute For , National Institutes Of Health , Cure Alzheimer Foundation , Artificial Intelligence Laboratory , Religious Orders , Aging Project , Carles Boix Phd , National Institutes , Cure Alzheimer , Single Cell Rna Sequencing , Cognitive Resilience , Hromatin Erosion , Dna Damage , Li Huei Tsai , Manolis Kellis ,

Study reveals potential for N-acetylcysteine (NAC) to reduce obesity complications

A new study has found that N-acetylcysteine (NAC), an antioxidant derived from the amino acid L-cysteine, could reduce some complications caused by obesity as well as age. ....

Diba Behtaj , Hamid Zand , Sepideh Fazeli Taherian , Mohammad Hassan Sohouli , Maryam Abbasi , Nasser Malekpour Alamdari , Ghazaleh Eslamian , Ntioxidants Carotenoids , Weight Management , Dna Damage , Oxidative Stress , Insulin Resistance ,