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Noninvasive technique reveals how cells' gene expression changes over time | MIT News | Massachusetts Institute of Technology

A new method can track changes in live cell gene expression over extended periods of time. Based on Raman spectroscopy, the method doesn’t harm cells and can be performed repeatedly. ....

Tommaso Biancalani , Koseki Kobayashi Kirschvink , Jian Shu , Aviv Regev , Jeon Woong Kang , Broad Institute Of Harvard , Genentech Research , Us National Institute Of Biomedical Imaging , Helen Hay Whitney Foundation , Harvard Medical School , Naito Foundation Overseas Postdoctoral Fellowship , Us National Institutes Of Health , Department Of Biology , Broad Institute , Early Development , Laser Biomedical Research Center , Howard Hughes Medical Institute , Biomedical Research Center , Japan Society , Science Postdoctoral Fellowship , Overseas Researchers , Mathworks Fellowship , Biomedical Imaging , Klarman Cell , Raman Microscopy , Single Cell Rna Sequencing ,

Decoding the complexity of Alzheimer's disease | MIT News | Massachusetts Institute of Technology

Using more than 2 million cells from over 400 postmortem brain samples, MIT researchers performed the largest-scale analysis of the genomic, epigenomic, and transcriptomic changes that occur in every cell type in the brains of Alzheimer’s patients. ....

United States , Li Huei Tsai , Manolis Kellis , Matheus Victor , Hansruedi Mathys , Carles Boix , Zhuyu Verna Peng , Benjamin James , Xushen Xiong , Vishnu Dileep , Broad Institute , Picower Institute For , National Institutes Of Health , Cure Alzheimer Foundation , Artificial Intelligence Laboratory , Religious Orders , Aging Project , Carles Boix Phd , National Institutes , Cure Alzheimer , Single Cell Rna Sequencing , Cognitive Resilience , Hromatin Erosion , Dna Damage , Li Huei Tsai , Manolis Kellis ,

Imaging Mass Cytometry May Identify Therapeutic Targets in ccRCC

The tumor-immune evasion cell networks in clear cell renal cell carcinoma may be captured and classified using imaging mass cytometry, an orthogonal approach with the potential for increased cost-efffectiveness and accuracy compared with single-cell RNA sequencing. ....

Hartlandw Jackson , Lunenfeld Tanenbaum Research Institute Of Sinai Health , Lunenfeld Tanenbaum Research Institute , Ontario Institute For Cancer Research , Kidney Cancer Research Summit , Princess Margaret Cancer Center , Cancer Research Summit , Sinai Health , Ontario Institute , Cancer Research , Single Cell Biology , Imaging Mass , Tumor Immune Evasion Cell Networks , Clear Cell Renal Carcinoma , Imaging Mass Cytometry , Single Cell Rna Sequencing ,

Mechanism revealed for COVID-19-related loss of smell

Olfactory tissue biopsies help researchers discover the mechanism responsible for COVID-19-related loss of smell, along with other long COVID symptoms. ....

Bradleyj Goldstein , Elissa Wolfson , Duke Health , Science Advisory Board , Science Translational Medicine , Covid 19 , Long Covid , Ost Acute Covid 19 , Ars Cov 2 , Ost Covid Smell Loss , Loss Of Smell , T Cells , Inflammatory Response , Nflammatory Mechanism , Olfactory Epithelium , Lfactory Sensory Neurons , Lfactory Nerve Cells , Single Cell Analysis , Single Cell Rna Sequencing , Lfactory Tissue Biopsies , Lfactory Mucosa Biopsies , T Cell Mediated Mechanisms , Eripheral Olfactory System , Duke Health ,

Scientists chart how exercise affects the body

MIT and Harvard Medical School researchers mapped out many of the cells, genes, and cellular pathways that are modified by exercise or a high-fat diet. They hope their findings will help guide the design of drugs that might mimic some beneficial effects of exercise. ....

United States , Laurie Goodyear , Maria Vamvini , Manolis Kellis , Jiekun Yang , Pasquale Nigro , Broad Institute , Artificial Intelligence Laboratory , Joslin Diabetes Center , National Institutes Of Health , Harvard Medical School , Novo Nordisk Research Center , National Institutes , Adipose Tissue , Single Cell Rna Sequencing , Mesenchymal Stem Cells , Extracellular Matrix , Manolis Kellis , Laurie Goodyear , Jiekun Yang , Maria Vamvini , Pasquale Nigro ,