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ZIP7: A novel target for treating degenerative diseases associated with misfolded proteins

Proteins are the workhorses of life. Organisms use them as building blocks, receptors, processors, couriers and catalysts. ....

United States , Morgan Mutch , Denise Montell , Dennis Clegg , Xiaoran Guo , Santa Barbara , Foundation Fighting Blindness , National Institute , Department Of Molecular , University Of California , Developmental Cell , Senior Author , Duggan Professor , Distinguished Professor , Professor Dennis Clegg , General Medical , Cell Biology , Developmental Biology , Embryonic Development , Retinitis Pigmentosa , Wound Healing ,

Atomic-level structural models of enzymes provide disease insights

When nucleic acids like DNA or RNA build up in a cell's cytoplasm, it sets off an alarm call for the immune system. ....

Amanda Gavin , Xueyong Zhu , Fangkun Luan , Ziqi Feng , Jeanne Matteson , Jenny Tran , Ian Wilson , David Nemazee , Linghang Peng , National Institutes Of Health , Department Of Immunology , Computational Biology At Scripps Research , Scripps Research Institute , Department Of Integrative Structural , Scripps Research , Meng Yuan , Integrative Structural , Computational Biology , Deli Huang , National Institutes , Skaggs Institute , Chemical Biology , Structural Biology , Lzheimer 39s Disease , Immune System , Lupus Erythematosus ,

Study reveals novel mechanism for longevity of oocytes

Oocytes are immature egg cells that develop in almost all female mammals before birth. The propagation of future generations depends on this finite reserve of cells surviving for many years without incurring damage. ....

Comunidad Autonoma De Cataluna , Gabriele Zaffagnini , Centre For Genomic Regulation , Genomic Regulation , Group Leader , Oocyte Biology , Cellular Dormancy , Endolysosomal Vesicular Assemblies , Neurodegenerative Diseases , Protein Aggregation ,

Immune protein Ku70 key in fighting bowel cancer

Study establishes Ku70's role in tumor suppression, showing that reduced expression or mutations in this DNA repair protein significantly increase intestinal cancer risk. ....

Dextran Sodium Sulfate , Real Time Polymerase Chain Reaction , Active Ras Detection , Bowel Cancer , Cell Line , Cell Nucleus , Colorectal Cancer , Intestinal Cancer , Ignaling Pathway ,

New approach to Parkinson's treatment focuses on stopping toxic protein production

Like the Greek mythological beast with a snake's tail and two ferocious heads, a potential Parkinson's medicine created in the lab of chemist Matthew Disney, Ph.D., is also a type of chimera bearing two heads. ....

United States , M Maral Mouradian , Matthew Disney , Peiyuan Zhang , Uf Health , Massachusetts Institute Of Technology , Proceedings Of The National Academy Sciences , Rutgers University , Institute Professor , Skaggs Graduate School Of Chemical , National Academy , Herbert Wertheim , Biomedical Innovation , Skaggs Graduate School , Biological Sciences , Massachusetts Institute ,