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Oocytes outsmart toxic proteins to preserve long-term female fertility

Oocytes outsmart toxic proteins to preserve long-term female fertility
sciencedaily.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencedaily.com Daily Mail and Mail on Sunday newspapers.

Comunidad Autonoma De Cataluna , Gabriele Zaffagnini , Centre For Genomic Regulation , Genomic Regulation , Group Leader , Oocyte Biology , Cellular Dormancy , Endolysosomal Vesicular ,

Oocytes outsmart toxic proteins to preserve long-term female fertility

Oocytes outsmart toxic proteins to preserve long-term female fertility
phys.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from phys.org Daily Mail and Mail on Sunday newspapers.

Comunidad Autonoma De Cataluna , Gabriele Zaffagnini , Gabriele Zaffagnini Centro , Centro De Regulaci , Genomic Regulation , Group Leader , Oocyte Biology , Cellular Dormancy , Endolysosomal Vesicular Assemblies ,

Oocytes outsmart toxic proteins to preserve l

<p>The accumulation of misfolded or damaged proteins in long-lived, non-dividing cells like neurons are linked to neurodegenerative diseases like Alzheimer’s. A study in the journal <em>Cell </em>finds that the build-up of these toxic proteins also influences oocyte quality and female fertility. The researchers discovered that mouse oocytes have specialised structures which roam the cytoplasm and act like a clean-up crew which capture and hold onto protein aggregates, rendering them harmless. Failure to degrade the toxic proteins led to the formation of defective eggs. 3 in 5 (60%) of mouse embryos that inherited the toxic proteins failed to complete the very earlies stages of development. The study presents a new frontier to explore the underlying mechanisms of poor oocyte quality, which is the leading cause of female infertility.</p>
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Comunidad Autonoma De Cataluna , Gabriele Zaffagnini , Method Of Research , Centre For Genomic Regulation , Genomic Regulation , Group Leader , Oocyte Biology , Cellular Dormancy , Endolysosomal Vesicular Assemblies ,

Study reveals novel mechanism for longevity of oocytes

Oocytes are immature egg cells that develop in almost all female mammals before birth. The propagation of future generations depends on this finite reserve of cells surviving for many years without incurring damage. ....

Comunidad Autonoma De Cataluna , Gabriele Zaffagnini , Centre For Genomic Regulation , Genomic Regulation , Group Leader , Oocyte Biology , Cellular Dormancy , Endolysosomal Vesicular Assemblies , Neurodegenerative Diseases , Protein Aggregation ,