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FIND Cell is a new tool that digitizes cell culture to enable reproducible biomedical science


FIND Cell is a new tool that digitizes cell culture to enable reproducible biomedical science
New cloud based software platform reduces research costs and improves speed and reliability
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NEW YORK, May 19, 2021 /PRNewswire/ Lack of reproducibility is a critical problem in biomedical science, wasting both time and billions of dollars every year. The Correspondence
Tracking cell lineages improves research reproducibility , published today in
Nature Biotechnology, lays the scientific foundation for a brand-new software platform called
FIND Cell; a unique tool that aims to improve reproducibility of cell-based science.
FIND Cell (available at https://findgen.bio/) integrates daily cell line tracking with genetic verification. It enables scientists to digitize, organise, verify, and find their cell culture related information – which is critical for biomedical research. ....

New York , United States , New York University , Neville Sanjana , Tyler Joseph , Sophie Zaaijer , York Genome Center , York University , Nature Biotechnology , Sophie Zaaijer Phd , Principal Investigators , Cornell Tech , Core Faculty Member , New York Genome Center , Assistant Professor , New York City Based , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , புதியது யார்க் பல்கலைக்கழகம் , நெவில் சஞ்சனா , டைலர் ஜோசப் , யார்க் மரபணு மையம் , யார்க் பல்கலைக்கழகம் , இயற்கை உயிரி தொழில்நுட்பவியல் , ப்ரிந்ஸிபல் புலனாய்வாளர்கள் , கார்னெல் தொழில்நுட்பம் ,

Novel integrative genetic screening platform offers insights into role of DNA accessibility in cancer


Novel integrative genetic screening platform offers insights into role of DNA accessibility in cancer
In a new resource for the scientific community, published today in
Nature Biotechnology, researchers in the lab of Neville Sanjana, PhD, at the New York Genome Center (NYGC) and New York University (NYU) developed CRISPR-sciATAC, a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide.
With this technology, they profile changes in genome organization and create a large-scale atlas of how loss of individual chromatin-altering enzymes impacts the human genome. The new method harnesses the programmability of the gene editing system CRISPR to knock-out nearly all chromatin-related genes in parallel, offering researchers deeper insights into the role of DNA accessibility in cancer and in rare diseases involving chromatin. ....

New York , United States , New York University , Neville Sanjana , Noa Liscovitch Brauer , Jay Shendure , Emily Henderson , Sanjana Lab , Innovation Technology Lab , York Genome Center , University Of Washington , Grossman School Of Medicine , Study Co , York University , Nature Biotechnology , New York Genome Center , Study Co Author , Postdoctoral Fellow , Antonino Montalbano , Core Faculty Member , Assistant Professor , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , புதியது யார்க் பல்கலைக்கழகம் , நெவில் சஞ்சனா , ஜெய் ஷெண்டுரே ,

Single-cell CRISPR technology deciphers role of chromatin accessibility in cancer


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IMAGE: CRISPR-sciATAC is a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide. The new method harnesses the programmability of the gene editing system.
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Credit: Sanjana Lab of New York Genome Center and NYU
NEW YORK, NY (April 29, 2021) - In a new resource for the scientific community, published today in
Nature Biotechnology, researchers in the lab of Neville Sanjana, PhD, at the New York Genome Center (NYGC) and New York University (NYU) developed CRISPR-sciATAC, a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide. With this technology, they profile changes in genome organization and create a large-scale atlas of how loss of individual chromatin-altering enzymes impacts the human genome. The new method harnesses the programmability of the gene ed ....

New York , United States , Memorial Sloan Kettering Cancer Center , Rockefeller University , New York University , Cold Spring Harbor Laboratory , Hospital For Special Surgery , American Museum Of Natural History , Columbia University , Neville Sanjana , Noa Liscovitch Brauer , Karen Zipern , Jay Shendure , Sanjana Lab , York Genome Center , Rutgers Cancer Institute Of New Jersey , University Of Washington , Grossman School Of Medicine , Roswell Park Cancer Institute , York University , Hackensack Meridian Health , York Stem Cell Foundation , Northwell Health , Albert Einstein College Of Medicine , Princeton University , Stony Brook University ,