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CRISPR and single-cell sequencing pinpoint causal genetic variants for traits and diseases: STING-seq provides roadmap to identify variants and genes, enabling deeper understanding of the noncoding genome and targets for therapies

CRISPR and single-cell sequencing pinpoint causal genetic variants for traits and diseases: STING-seq provides roadmap to identify variants and genes, enabling deeper understanding of the noncoding genome and targets for therapies
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CRISPR and single-cell sequencing pinpoint ca

A major challenge in human genetics is understanding which parts of the genome drive specific traits or contribute to disease risk. This challenge is even greater for genetic variants found in the 98% of the genome that does not encode proteins.

A new approach developed by researchers at New York University and the New York Genome Center combines genetic association studies, gene editing, and single-cell sequencing to address these challenges and discover causal variants and genetic mechanisms for blood cell traits. ....

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Meet The New Yorkers Hunting Down The Coronavirus Variants

Meet The New Yorkers Hunting Down The Coronavirus Variants
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Mutations have made coronavirus EIGHT times more infectious than original Wuhan variant – study – Voice Of Vienna

Home / International / Mutations have made coronavirus EIGHT times more infectious than original Wuhan variant – study
Mutations have made coronavirus EIGHT times more infectious than original Wuhan variant – studyInternational
2021-02-19,
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New research has found that a mutation in the spike protein of SARS-CoV-2, present in variants from the United Kingdom, South Africa, and Brazil, can make the virus up to eight times more infectious than the original.
The new research into the D614G mutation on the spike protein in SARS-CoV-2, present in all the latest variants currently plaguing healthcare systems the world over, was led by researchers at New York University, the New York Genome Center, and Mount Sinai. ....

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Mutation in spike protein makes coronavirus eight times more infectious, study finds

Mutation in spike protein makes coronavirus eight times more infectious, study finds
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New York, Feb 18 (PTI) The D614G mutation in the spike protein of the novel coronavirus renders it up to eight times more infectious in human cells than the initial virus that originated in China, according to a study.
The spike protein is used by SARS-CoV-2, the virus which causes COVID-19, to enter the host cells. The research, published in the journal eLife, confirms findings that D614G one of several mutations in the concerning variants that have emerged in the UK, South Africa, and Brazil makes the coronavirus more transmissible. The mutation has reached near universal prevalence and is included in all current variants of concern, said Neville Sanjana, assistant professor of biology at New York University (NYU) in the US. Confirming that the mutation leads to more transmissibility may help explain, in part, why the virus has spread so rapidl ....

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