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Osimertinib Combo Lessens CNS Progression in EGFR NSCLC

Central nervous system (CNS) progression was reduced with osimertinib plus chemotherapy for patients with EGFR-mutated non-small cell lung cancer plus CNS metastases. ....

France General , Davida Litman , Institut Gustave Roussy , David Planchard , European Society Of Medical Oncology Congress , Medical Oncology Congress , Common Terminology Criteria , Adverse Events , Full Analysis , Non Measurable Lesions ,

Pyrotinib versus placebo in combination with trastuzumab and docetaxel as first line treatment in patients with HER2 positive metastatic breast cancer (PHILA): randomised, double blind, multicentre, phase 3 trial

Objective To assess the efficacy and safety of pyrotinib (an irreversible pan-HER (human epidermal growth factor receptor) inhibitor), trastuzumab, and docetaxel compared with placebo, trastuzumab, and docetaxel for untreated HER2 positive metastatic breast cancer.

Design Randomised, double blind, placebo controlled, multicentre, phase 3 trial.

Setting 40 centres in China between 6 May 2019 and 17 January 2022.

Participants 590 female patients (median age 52 (interquartile range 46-58) years) with untreated HER2 positive metastatic breast cancer.

Interventions Eligible patients were randomised 1:1 to receive either oral pyrotinib (400 mg once daily) or placebo, both combined with intravenous trastuzumab (8 mg/kg in cycle 1 and 6 mg/kg in subsequent cycles) and docetaxel (75 mg/m2) on day 1 of each 21 day cycle. Randomisation was stratified by treatment history of trastuzumab in the (neo)adjuvant setting and hormone receptor status. Patients, investigators, a ....

Eteläuomen Läi , Pconclusions Pyrotinib , Jiaman Lin Hengrui , Tengfei Zhang , Demets Obrien Fleming , Kaijing Zhao Hengrui , Eastern Cooperative Oncology Group , Human Genetic Resource Administration Of China , Drug Administration , Jiangsu Hengrui Pharmaceuticals , China National Medical Products Administration , Innovation Fund For Medical Sciences , Response Evaluation Criteria , Solid Tumors , National Cancer Institute , Common Terminology Criteria , Adverse Events , Good Clinical Practice , Human Genetic Resource Administration , Jiaman Lin , Kaijing Zhao , Good Publication Practice , Medical Sciences , Jiangsu Hengrui , Open Access , Creative Commons Attribution Non Commercial ,

Advancing Chiropractic Safety: CDAHK Eric Chu Wins Coveted IBCE Award at 17th WFC Biennial Congress

Advancing Chiropractic Safety: CDAHK Eric Chu Wins Coveted IBCE Award at 17th WFC Biennial Congress
einnews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from einnews.com Daily Mail and Mail on Sunday newspapers.

Hong Kong , Eric Chu , Eric Chun Pu Chu , International Board Of Chiropractic Examiners , Chiropractic Doctors Association Of Hong Kong , World Federation Of Chiropractic Quarterly , World Federation Of Chiropractic , World Federation , Chun Pu Chu , Chiropractic Doctors Association , International Board , Chiropractic Examiners , Poster Award , Nature Scientific Reports , Retrospective Analysis , Severe Adverse Events Among Recipients , Chiropractic Spinal Manipulative , Common Terminology Criteria , Adverse Events , Manual Therapies , Chiropractic Quarterly , Oxford Case , David Chapman Smith Honor ,

Resistant potato starch usage found to be feasible and safe for hematopoietic stem cell transplantation patients

The use of resistant potato starch (RPS), to modify gut microbial metabolism. ....

Narsil Shutterstock , Nature Medicine , Common Terminology Criteria , Adverse Events , Fatty Acids , Short Chain Fatty Acids ,

Paying for Cancer Care Differently: A Look Into the Future

Coverage from The US Oncology Network Payer Transformation Summit, held September 27-29, 2023, in Atlanta, Georgia. ....

United States , North Carolina , University Of North Carolina , Fort Worth , Ethan Basch , Gunjan Sharma , Basch Hudson , Japsenb Humana , Humana Lily Pham , Saulet Brewer , Jenny Fernandez , Jason Hammonds , Wilfong Hammonds , Angela Storseth , Shannon Hough , Kathryn Hudson , Debra Patt , Lalan Wilfong , Rahul Sangal , Travis Brewer , Sach Jain , Hattonr Optum , Lora Markley , Deirdre Saulet , School Of Medicine , Division Of Oncology ,