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Harnessing the Potential of High-Performance Organic Cathodes

Zinc, which is inexpensive, abundant, and ecologically friendly, could be the answer to better batteries, but there is a huge issue: In terms of power output, aqueous zinc ion batteries (AZIBs) cannot compete with lithium-ion batteries. To see what electrode material composition could bring AZIBs up to par, a Chinese research team created two organic frameworks with the same elements but arranged differently. ....

Fanbin Zeng , Tengfei Zhang , Meilin Li , Cuiping Han , Skyla Baily , Qingming Liu , Jun Zhou , Senlin Li , Research Foundation , Vehicle Battery Technology Industry , Vehicle Battery Technology , Chinese Academy Of Sciences , China Postdoctoral Science Foundation , Energy Materials , Tsinghua University , Study Co , Outstanding Youth Basic Research Project Of Shenzhen , Shenzhen Institute Of Advanced Technology , Towngas Energy Academy , National Natural Science Foundation Of China , Study Co First Author , Shenzhen Institute , Advanced Technology , Chinese Academy , Vehicle Battery Technology Industry Focus , Guangdong Basic ,

Pyrotinib versus placebo in combination with trastuzumab and docetaxel as first line treatment in patients with HER2 positive metastatic breast cancer (PHILA): randomised, double blind, multicentre, phase 3 trial

Objective To assess the efficacy and safety of pyrotinib (an irreversible pan-HER (human epidermal growth factor receptor) inhibitor), trastuzumab, and docetaxel compared with placebo, trastuzumab, and docetaxel for untreated HER2 positive metastatic breast cancer.

Design Randomised, double blind, placebo controlled, multicentre, phase 3 trial.

Setting 40 centres in China between 6 May 2019 and 17 January 2022.

Participants 590 female patients (median age 52 (interquartile range 46-58) years) with untreated HER2 positive metastatic breast cancer.

Interventions Eligible patients were randomised 1:1 to receive either oral pyrotinib (400 mg once daily) or placebo, both combined with intravenous trastuzumab (8 mg/kg in cycle 1 and 6 mg/kg in subsequent cycles) and docetaxel (75 mg/m2) on day 1 of each 21 day cycle. Randomisation was stratified by treatment history of trastuzumab in the (neo)adjuvant setting and hormone receptor status. Patients, investigators, a ....

Eteläuomen Läi , Pconclusions Pyrotinib , Jiaman Lin Hengrui , Tengfei Zhang , Demets Obrien Fleming , Kaijing Zhao Hengrui , Eastern Cooperative Oncology Group , Human Genetic Resource Administration Of China , Drug Administration , Jiangsu Hengrui Pharmaceuticals , China National Medical Products Administration , Innovation Fund For Medical Sciences , Response Evaluation Criteria , Solid Tumors , National Cancer Institute , Common Terminology Criteria , Adverse Events , Good Clinical Practice , Human Genetic Resource Administration , Jiaman Lin , Kaijing Zhao , Good Publication Practice , Medical Sciences , Jiangsu Hengrui , Open Access , Creative Commons Attribution Non Commercial ,