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Tumor cells' 'ferroaddiction' can be exploited to deliver powerful anticancer drugs

Researchers at the University of California, San Francisco, have discovered that cells carrying the most common mutation found in human cancer accumulate large amounts of ferrous iron and that this "ferroaddiction" can be exploited to specifically deliver powerful anticancer drugs without harming normal, healthy cells. ....

United States , San Francisco , Erica Collisson , Honglin Jiang , Adamr Renslo , Emily Henderson , University Of California , Department Of Pharmaceutical Chemistry , Department Of Medicine , Experimental Medicine , Pharmaceutical Chemistry , Acute Myeloid Leukemia , Cell Proliferation , Cell Signaling , Colorectal Cancer , Myeloid Leukemia ,

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Researchers led by Christopher Garcia of the Ludwig Center at Stanford University have solved the long-sought structure of a large signaling protein involved in responses to infection, inflammation, the generation of immune cells and when dysregulated by mutation-; the emergence of blood cancers known as myeloproliferative neoplasms. ....

Christopher Garcia , Emily Henderson , Ludwig Center At Stanford University , Ludwig Center , Stanford University , Cell Signaling ,