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Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite

Reactive compounds cause cellular damage that is suspected to contribute to aging and neurodegenerative diseases. Oxidative stress and environmental factors likely contribute to this. Here we report that an enzyme mutated in Parkinson’s disease can prevent damage of metabolites and proteins caused by a metabolite from the central pathway of sugar metabolism. Inactivation of this enzyme in model systems, ranging from flies to human cells, leads to the accumulation of a wide range of damaged metabolites and proteins. Thus, this enzyme represents a highly conserved strategy to prevent damage in cells that metabolize sugars. Overall, we discovered a fundamental link between carbohydrate metabolism and a type of cellular damage that might contribute to the development of Parkinson’s disease.

Mass spectrometry proteomics data have been deposited at ProteomeXchange, [www.proteomexchange.org/][1] (accession no. PXD029410) via the PRIDE partner repository ([62][2]). Processed mass sp ....

United Kingdom , Fondation Contre Le , Deutsche Forschungsgemeinschaft , European Union Horizon , Didier Trono University Of Geneva , Eric Fearon University Of Michigan , University Animal Welfare Committee , European Research Council , Jp Bolanos University Of Salamanca , Feng Zhang Massachusetts Institute Of Technology , Universal Problem , Long Standing Enigma , Proteins Provides , Pleiotropic Effects , Phosphatases That Convertn Phosphoglyceroyl , N Glyceroyl Adducts Remain , Animal Welfare , Recombinant Proteins , Orbitrap Fusion Lumos , Proteome Discoverer , Cell Signaling , Cell Biolabs , Feng Zhang , Massachusetts Institute , Eric Fearon , Ann Arbor ,

How plants respond to heat stress | PressReleasePoint

Plants, like other organisms, can be severely affected by heat stress. To increase their chances of survival, they activate the heat shock response, a molecular pathway also employed by human and animal cells for stress protection. ....

United States , Brigitte Poppenberger , Horticultural Crops , Food Security , Branches Of Biology , Cell Signaling , Cellular Processes , Heat Shock Factor , Heat Shock Protein , Heat Shock Response , Signal Transduction , Transcription Factors ,