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PFOB@LIP-Tet to treat dry eye disease


8 Cytokines, including Il-1β, TNF-α, and PEG
2 and VEGF, have been certified to play an important role in DED, and by inhibiting expression of those cytokines, symptoms of DED could be significantly alleviated.
35–39 Traditional anti-inflammatory agents like corticosteroids would result in disastrous incidence if inappropriately applied, including intraocular hypertension and cataract,
10 which narrows its use in DED therapy. Therefore, an effective anti-inflammation agent with less impact on intraocular pressure is worthy of exploration. Tet, a plant alkaloid isolated from a traditional Chinese herb,
11 is initially used as an anti-inflammation agent to treat rheumatoid arthritis. It has been demonstrated that Tet could suppress the release of IL-1β, TNF-α, VEGF and PEG ....

South Korea , United States , Corden Liestal , Zealand White , Statens Seruminstitut , Allergan Inc , Becton Dickinson , Ruixi Biological Technology Xian , Animal Ethics Committee Of Chongqing Medical University , Animal Ethics Committee , Observations Of Physicochemical Properties Liposomes , Ccri Inc , Animal Research Center , Graphpad Software , University Animal Research Center , Aldrich Co , Ruixi Biological Technology , Shanchuan Biotechnology , Fine Biotech , Physicochemical Properties , Tet Loading , Its Release , New Zealand White , Chongqing Medical University , Chongqing Medical , Cell Counting ,

Otto Bremer Trust awards 190 grants totaling $11.4 million


Otto Bremer Trust awards 190 grants totaling $11.4 million
Times Report
Crookston Times
    The Otto Bremer Trust has awarded $11,473,300 in grants and program-related investments to 190 organizations in Minnesota, Montana, North Dakota, and Wisconsin, as part of its most recent grantmaking cycle.
    Following is a full list of grants awarded in the Red River Region, as well as selected grants in northern Minnesota closest to Crookston.
Red River Region
    CCRI, Inc., Moorhead, MN, $60,000. To provide mental health and in-home family support to people with disabilities in Clay County.
    Community Health Service Inc., Moorhead, MN, $100,000. For general operations to improve awareness of and targeted access to affordable healthcare for low-income individuals ....

United States , Leech Lake , Crow Wing County , West Fargo , North Dakota , Grand Portage Reservation , Waite Park , Cook County , International Falls , Clay County , River Valley , Red River , Sawtooth Mountain Clinic , Grand Forks , Grand Marais , Cass Lake , Life House Inc , Ely Community Health Center , Community Violence Intervention Center Inc , Lidgerwood Progressive Development Corporation , Sexual Assault Services Inc , Community Action Duluth , Otto Bremer , Dakota Autism Center Inc , Community Health Service Inc , Dakota State University ,