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Circulating myeloid-derived MMP8 in stress susceptibility and depression

Psychosocial stress has profound effects on the body, including the immune system and the brain1,2. Although a large number of pre-clinical and clinical studies have linked peripheral immune system alterations to stress-related disorders such as major depressive disorder (MDD)3, the underlying mechanisms are not well understood. Here we show that expression of a circulating myeloid cell-specific proteinase, matrix metalloproteinase 8 (MMP8), is increased in the serum of humans with MDD as well as in stress-susceptible mice following chronic social defeat stress (CSDS). In mice, we show that this increase leads to alterations in extracellular space and neurophysiological changes in the nucleus accumbens (NAc), as well as altered social behaviour. Using a combination of mass cytometry and single-cell RNA sequencing, we performed high-dimensional phenotyping of immune cells in circulation and in the brain and demonstrate that peripheral monocytes are strongly af ....

United States , South Korea , Lookeren Campagne , Brunstein Klomek , J Health Soc , Research Version American Psychiatric Association , Psychiatry Rep , Cancer Biol , Open Sci , Growth Factor Rev , Cell Biol , Structured Clinical Interview , American Psychiatric Association ,

Chicago prep school's 'negligent behavior' toward cyberbullying led to student's suicide, parents allege

This story may contain details that are disturbing.If you or someone you know is having thoughts of suicide, please contact the National Suicide Prevention Lifeline at 988.In January 2022, Robert and Rose Bronstein's 15-year-old son died by suicide after The Latin School of Chicago allegedly ignored the teenager's complaints about bullying on social media from ....

New York , United States , New Jersey , Lawrenceville School , Rose Bronstein , Robert Bronstein , Shay Arnon , Randall Dunn , Jack Reid , Elina Visoki , Brunstein Klomek , Latin School Of Chicago , Department Of Education , Latin School , National Suicide Prevention Lifeline , Scarlet Letter , Bridget Hennessy , Students Randall Dunn , National Association , Independent Schools , Rye Country Day , New York City , Fox News , Anat Brunstein Klomek , Buckets Over Bullying ,

Chicago prep school's 'negligent behavior' toward cyberbullying led to student's suicide, parents allege

Two parents say The Latin School of Chicago failed to report their 15-year-old son's concerns about cyberbullying before he died by suicide in January 2022. ....

New York , United States , Lawrenceville School , New Jersey , Robert Bronstein , Rose Bronstein , Jack Reid , Randall Dunn , Brunstein Klomek , Department Of Education , Latin School , Latin School Of Chicago , National Suicide Prevention Lifeline , Scarlet Letter , Bridget Hennessy , Students Randall Dunn , National Association , Independent Schools , Rye Country Day , New York City , Fox News , Buckets Over Bullying ,

Chicago prep school's 'negligent behavior' toward cyberbullying led to student's suicide, parents allege

In January 2022, Robert and Rose Bronstein's 15-year-old son died by suicide after The Latin School of Chicago allegedly ignored the teenager's complaints about bullying on social media from his peers. ....

New Jersey , United States , Lawrenceville School , New York , Rose Bronstein , Randall Dunn , Brunstein Klomek , Jack Reid , Robert Bronstein , Latin School , National Suicide Prevention Lifeline , Call The National Suicide Prevention Lifeline , Latin School Of Chicago , Department Of Education , Latin School Of View , National Suicide Prevention , Crisis Text Line , Scarlet Letter , Bridget Hennessy , Students Randall Dunn , Google Street , National Association , Independent Schools , Rye Country Day , New York City , Fox News ,

Male school bullies and their victims are more likely to commit violent offenses as adults

A longitudinal study in Finland shows that male school bullies and male victims of bullying are more likely to commit violent offences as adults. This association was much less clear in females. The study was published in the European Child & Adolescent Psychiatry. . ....

Lauri Sillanm , Henrik Elonheimo , Elina Tiiri , Jaakko Uotila , Andre Sourander , Brunstein Klomek , Finnish National Police , Finnish National Police Register , European Child , Finnish Nationwide , Cohort Study , Rutter Teacher , Anat Brunstein Klomek ,