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'Background noise' in neurotransmission helps keep nerve connections young


Background noise in neurotransmission helps keep nerve connections young
Neurons communicate through rapid electrical signals that regulate the release of neurotransmitters, the brain s chemical messengers. Once transmitted across a neuron, electrical signals cause the juncture with another neuron, known as a synapse, to release droplets filled with neurotransmitters that pass the information on to the next neuron. This type of neuron-to-neuron communication is known as evoked neurotransmission.
However, some neurotransmitter-packed droplets are released at the synapse even in the absence of electrical impulses. These miniature release events or minis have long been regarded as background noise.
Brian McCabe, Director of the Laboratory of Neural Genetics and Disease and a Professor in the EPFL Brain Mind Institute ....

Soumya Banerjee , Brian Mccabe , Emily Henderson , Nature Communications , Brain Mind Institute , Laboratory Of Neural Genetics , Neural Genetics , சௌமிய பானர்ஜி , பிரையன் ம்க்கேப் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , மூளை மனம் நிறுவனம் , நரம்பியல் ஜெநெடிக்ஸ் ,

Bile acids trigger satiety in the brain


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IMAGE: Neuronal cell line (mHypoE-N41) transfected with NPY-mCherry (in red) and stained with phalloidin to label the actin cytoskeleton (in green). In this cell TGR5 was activated by its selective agonist.
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Credit: EPFL
Our brain is usually well protected from uncontrolled influx of molecules from the periphery thanks to the blood-brain barrier, a physical seal of cells lining the blood vessel walls. The hypothalamus, however, is a notable exception to this rule. Characterized by leaky blood vessels, this region, located at the base of the brain, is exposed to a variety of circulating bioactive molecules. This anatomical feature also determines its function as a rheostat involved in the coordination of energy sensing and feeding behavior. ....

Alessia Perino , Kristina Schoonjans , Brain Mind Institute , Takedag Coupled , Mind Institute , Bertarelli Platform , Gene Therapy , Medicine Health , Diet Body Weight , Eating Disorders Obesity , Metabolism Metabolic Diseases , மூளை மனம் நிறுவனம் , மனம் நிறுவனம் , கீந் சிகிச்சை ,