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Covalent proteins? Enlaza views opportunity with $100M series A

“A white space opportunity.” That’s how Enlaza Therapeutics Inc. co-founder and CEO Sergio Duron described to BioWorld the company’s efforts to develop the first covalent biologics, an endeavor that has gained the backing of an impressive group of investors in a recently closed $100 million series A round. ....

Sergio Duron , Enlaza Therapeutics Inc , Enlaza Therapeutics , Enlaza Therapeutics Inc , Covalent Biologics , Bioworld Science , Newco News , Antibody Drug Conjugate , Series A ,

Human iPSCs restore muscle, function in monkeys with heart failure

Japanese researchers have transplanted human induced pluripotent stem cells (iPSCs) in a primate model of myocardial infarction and were able to restore heart muscle and function in monkeys. Developed by Tokyo-based Heartseed Inc., the grafted iPSCs consist of clusters of purified heart muscle cells (cardiomyocyte spheroids) that are injected into the myocardial layer of the heart. Published in Circulation on April 26, 2024, the study showed that the cardiomyocyte spheroids survived long term and showed improved contractile function with low occurrence of post-transplant arrhythmias. ....

Heartseed Inc , Tokyo Based Heartseed Inc , Bioworld Science , Heartseed Inc , Induced Pluripotent Stem Cells , Heart Failure , Drug Design , Rug Delivery And Technologies , Stem Cells ,

Gut microbe enzymes can produce universal donor blood cells

Researchers have identified enzymes in gut microorganisms that could cleave A and B antigens from red blood, transmuting them to O negative cells. This is “a decisive step forward” in the quest to develop a universal donor blood that can be administered to people of any blood group without eliciting a harmful immune response, according to Maher Abou Hachem of the Technical University of Denmark, who co-led the research. ....

Technical University Of Denmark , Maher Abou Hachem , Technical University , Bioworld Science , Universal Donor Blood , Blood Groups ,

Epigenetic changes can initiate cancer, no mutations required

A group of scientists from the French National Center for Scientific Research (CNRS) have overturned a scientific dogma by demonstrating, for the first time, that DNA mutations are not essential for the development of cancer. The researchers temporarily disrupted gene silencing led by Polycomb proteins in fruit flies, and observed that this could produce tumors caused only by epigenetic changes, without permanent changes to the genome. ....

Scientific Research , French National Center , Bioworld Science ,

Preserving autophagy protects from muscle aging

A protein whose expression decreases during aging could be key to preserving cellular maintenance mechanisms and preventing the progressive loss of muscle mass that occurs during aging. Scientists from the Institute for Research in Biomedicine (IRB) and the University of Barcelona (UB) have revealed the role of the TP53INP2 protein in autophagy and the effects of its reduction on skeletal muscle during aging. ....

Comunidad Autonoma De Cataluna , University Of Barcelona , Institute For Research , Bioworld Science , Muscle Atrophy , Institute For Research In Biomedicine , Muscle Aging , Altos Labs ,