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Human iPSCs restore muscle, function in monkeys with heart failure

Japanese researchers have transplanted human induced pluripotent stem cells (iPSCs) in a primate model of myocardial infarction and were able to restore heart muscle and function in monkeys. Developed by Tokyo-based Heartseed Inc., the grafted iPSCs consist of clusters of purified heart muscle cells (cardiomyocyte spheroids) that are injected into the myocardial layer of the heart. Published in Circulation on April 26, 2024, the study showed that the cardiomyocyte spheroids survived long term and showed improved contractile function with low occurrence of post-transplant arrhythmias.

Heartseed incTokyo based heartseed incBioworld scienceHeartseed incInduced pluripotent stem cellsHeart failureDrug designRug delivery and technologiesStem cells

Global Induced Pluripotent Stem Cell (iPSC) Industry

Dublin, April 29, 2024 (GLOBE NEWSWIRE) The

United statesUnited kingdomHera biolabsAxol bioscienceNevia bioMasayo takahashiJames thomsonTakara bioShinya yamanakaAsia pacificExacis biotherapeuticsNeukio biotherapeuticsCellgenix gmbDrug developmentCentury therapeutics incCynata therapeutics ltd

Heartseed Succeeds in Stable Production of High Purity Cardiomyocytes Using iPS Cells from I Peace, A Major Step Forward in Advancing Autologous Cardiac Regenerative Medicine

Heartseed Succeeds in Stable Production of High Purity Cardiomyocytes Using iPS Cells from I Peace, A Major Step Forward in Advancing Autologous Cardiac Regenerative Medicine
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Palo altoUnited statesKikuo yasuiHeartseed incI peace incBusiness wireChief operating officer

Using iPS Cells from I Peace, Heartseed Succeeds in Stable Production of High Purity Cardiomyocytes, A Major Step Forward in Advancing Autologous Cardiac Regenerative Medicine

/PRNewswire/ Leading GMP cell CDMO I Peace, Inc. (https://www.ipeace.com), specializing in induced pluripotent stem cells (iPSCs) and iPSC-derived cell.

Palo altoUnited statesShinya yamanakaKeiichi fukudaNovo nordiskKoji tanabeMinistry of educationI peace incCdmoi peace incKyoto universityTechnology award at academic startupsDepartment of cardiologyTechnology policy award at japan ventureSourcei peace incKeio universityI peace ltd

Heartseed Succeeds in Stable Production of High Purity Cardiomyocytes Using iPS Cells from I Peace,

TOKYO & PALO ALTO, Calif. (BUSINESS WIRE) #Heartseed Heartseed Inc. ("Heartseed"), a Tokyo-based biotechnology company developing iPSC-derived cardiomyocytes for heart failure and I Peace Inc. ("I Peace"), a leading GMP cell CDMO in Palo Alto, California, have collaborated to generate cardiomyocytes using multipl.

Palo altoUnited statesKikuo yasuiHeartseed incI peace incChief operating officer