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Patient Factors Predictive of Colchicine-Related Adverse Events in Gout

An observational study in the UK investigated the risk of adverse events related to colchicine prophylaxis after receiving allopurinol for gout. ....

Ram Bajpai , Clinical Practice Research Datalink , Keele University Ram Bajpai , Keele University , Hospital Episode Statistics , Arthritis Rheum , Rheumatology Guideline , Arthritis Rheumatol ,

A break in mitochondrial endosymbiosis as a basis for inflammatory diseases

Mitochondria retain bacterial traits due to their endosymbiotic origin, but host cells do not recognize them as foreign because the organelles are sequestered. However, the regulated release of mitochondrial factors into the cytosol can trigger cell death, innate immunity and inflammation. This selective breakdown in the 2-billion-year-old endosymbiotic relationship enables mitochondria to act as intracellular signalling hubs. Mitochondrial signals include proteins, nucleic acids, phospholipids, metabolites and reactive oxygen species, which have many modes of release from mitochondria, and of decoding in the cytosol and nucleus. Because these mitochondrial signals probably contribute to the homeostatic role of inflammation, dysregulation of these processes may lead to autoimmune and inflammatory diseases. A potential reason for the increased incidence of these diseases may be changes in mitochondrial function and signalling in response to such recent phenomena as obesity, dietary chan ....

Czech Republic , United States , Sardon Puig , Drug Discov , Cell Sci , Cell Biol , Arthritis Rheumatol , Global Burden , Disease Study , Evolutionary Biology , Acids Res , Death Differ , Allergy Immunol , Cell Rep , Target Ther , Del Nido ,

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A regular series on the latest clinical studies from around the world – and what they mean ‘in practice’ – compiled and written by Clare GP Dr Ray ....

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Arthritis and Colon Bacteria

Arthritis and Colon Bacteria
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TREMFYA® (guselkumab) Provides Sustained Improvements Across All Minimal Disease Activity Domains for Adults Living with Active Psoriatic Arthritis in Phase 3b Trial

TREMFYA® (guselkumab) Provides Sustained Improvements Across All Minimal Disease Activity Domains for Adults Living with Active Psoriatic Arthritis in Phase 3b Trial
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