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Rejuvenating stem cells in the aging brain of mice improve the regeneration of injured or diseased areas in the brain

Rejuvenating stem cells in the aging brain of mice improve the regeneration of injured or diseased areas in the brain
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Srikanth Ravichandran , Luxembourg Centre For Systems Biomedicine , German Cancer Research Center , University Of Luxembourg , Computational Biology Group , Luxembourg Centre , Systems Biomedicine , Antonio Del Sol , Del Sol ,

Novel computer-guided design tool helps increase the efficiency of cell conversions

Novel computer-guided design tool helps increase the efficiency of cell conversions
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United States , Shinya Yamanaka , Evan Appleton , Donald Ingber , George Church , Emily Henderson , Nature Communications , Technology Alliance , Harvard Medical School , Postdoctoral Fellow In Church , University Of Luxembourg , Regulatory Network , Basque Research , Harvard Wyss Institute For Biologically Inspired Engineering , Wyss Institute , Wyss Institute Synthetic Biology , Harvard Johna Paulson School Of Engineering , Health Sciences , Luxembourg Centre For Systems Biomedicine , Biologically Inspired Engineering , Antonio Del Sol , Computational Biology , Luxembourg Centre , Systems Biomedicine , Wyss Core Faculty , Synthetic Biology ,

A computational guide to lead cells down desired differentiation paths

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IMAGE: The collaborative team successfully used their computer-guided design tool IRENE to reconstruct the gene regulatory network controlling the identity of induced pluripotent stem cells (iPSCs).
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Credit: Wyss Institute at Harvard University
(BOSTON) There is a great need to generate various types of cells for use in new therapies to replace tissues that are lost due to disease or injuries, or for studies outside the human body to improve our understanding of how organs and tissues function in health and disease. Many of these efforts start with human induced pluripotent stem cells (iPSCs) that, in theory, have the capacity to differentiate into virtually any cell type in the right culture conditions. The 2012 Nobel Prize awarded to Shinya Yamanaka recognized his discovery of a strategy that can reprogram adult cells to become iPSCs by providing them with a defined set of gene-regulatory transcription factors (TFs). However, progres ....

Boston University , United States , University Of Massachusetts Medical School , Massachusetts Institute Of Technology , Dana Farber Cancer Institute , Tufts University , Pais Vasco , Spaulding Rehabilitation Hospital , Lucie Debroux , Shinya Yamanaka , Evan Appleton , Donald Ingber , George Church , Benjamin Boettner , Muhammad Ali , Nature Communications , Beth Israel Deaconess Medical Center , Technology Alliance , Charitable Foundation , Severo Ochoa Centre Of Excellence , Basque Research , Wyss Institute , Army Research Office , Wyss Institute Synthetic Biology , Harvard Johna Paulson School Of Engineering , Bizkaia Technology Park ,