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The selection landscape and genetic legacy of ancient Eurasians

The Holocene (beginning around 12,000 years ago) encompassed some of the most significant changes in human evolution, with far-reaching consequences for the dietary, physical and mental health of present-day populations. Using a dataset of more than 1,600 imputed ancient genomes1, we modelled the selection landscape during the transition from hunting and gathering, to farming and pastoralism across West Eurasia. We identify key selection signals related to metabolism, including that selection at the FADS cluster began earlier than previously reported and that selection near the LCT locus predates the emergence of the lactase persistence allele by thousands of years. We also find strong selection in the HLA region, possibly due to increased exposure to pathogens during the Bronze Age. Using ancient individuals to infer local ancestry tracts in over 400,000 samples from the UK Biobank, we identify widespread differences in the distribution of Mesolithic, Neolithic and Bronze Age an ....

United Kingdom , South Lanarkshire , Turkey General , Khorasane Shemali , Genomes Project Consortium , Regulation Of Inflammatory Signaling In Health , United Kingdom Biobank , Late Bronze , Acids Res , Project Consortium , Bronze Age , Central Asian , Allen Ancient , Chinese Han , Inflammatory Signaling , Simons Genome Diversity Project , Near East ,

New Genomics Databases Could Drive Major Breakthroughs

New Genomics Databases Could Drive Major Breakthroughs
discovermagazine.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from discovermagazine.com Daily Mail and Mail on Sunday newspapers.

United States , Elinor Karlsson , Darryl Leja , Gunnar Kaasen , David Reich , Benedict Paten , Harvard University , Human Pangenome Reference Consortium , Broad Institute , University Of California , University Of Massachusetts Chan Medical School , Getty Images , Massachusetts Chan Medical School , Zoonomia Project , Allen Ancient , January February ,

New Genomics Databases Could Drive Major Breakthroughs

New Genomics Databases Could Drive Major Breakthroughs
discovermagazine.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from discovermagazine.com Daily Mail and Mail on Sunday newspapers.

United States , Darryl Leja , Elinor Karlsson , David Reich , Benedict Paten , Gunnar Kaasen , University Of Massachusetts Chan Medical School , Broad Institute , Human Pangenome Reference Consortium , University Of California , Harvard University , Getty Images , Massachusetts Chan Medical School , Zoonomia Project , Allen Ancient , January February ,

New Study Explores Why Some People Have So Much Neanderthal DNA

New Study Explores Why Some People Have So Much Neanderthal DNA
gizmodo.com.au - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from gizmodo.com.au Daily Mail and Mail on Sunday newspapers.

Nordrhein Westfalen , Claudio Quilodr , University Of Geneva , Resource At Harvard Medical School , East Asian , Western European , Central Asia , Africa Homo , East Asia , Western Europe , Allen Ancient , Harvard Medical ,

Past human expansions shaped the spatial pattern of Neanderthal ancestry

Past human expansions shaped the spatial pattern of Neanderthal ancestry
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

Allen Ancient , Middle East , Full Eurasia , East Africa , East Asia , Last Glacial Maximum , Central Europe , Fertile Crescent , Bronze Age , Ancient Eurasia , Arabian Peninsula ,