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Interleukin-6 Suppresses Interleukin-2 Signaling to Prevent Allergic Asthma and Atopy

Interleukin-6 Suppresses Interleukin-2 Signaling to Prevent Allergic Asthma and Atopy
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Erin Mclaughlin , Dave Durell Hill , Holly Bachus , Alexanderf Rosenberg , Amberm Papillion , Crystal Lewis , University Of Alabama At Birmingham , Marnixe Heersink School Of Medicine , Department Of Medicine , Department Of Microbiology , Department Of Cell , National Institutes Of Health , Division Of Clinical Immunology , Ige Syndrome , Cytokine Signaling , Clinical Immunology , National Institutes , Integrative Biology ,

Long-lived antibody response predicted with memory B cell marker

Memory B cells play a critical role to provide long-term immunity after a vaccination or infection. In a study published in the journal Immunity, researchers describe a distinct and novel subset of memory B cells that predict long-lived antibody resp ....

Andhra Pradesh , Emory University School Of Medicine , United States , Emory University , Christopherm Tipton , Ignacio Sanz , Betty Mousseau , R Glenn King , Paula Goepfert , Esther Zumaquero , Alexanderf Rosenberg , Johne Bradley , Dfran Lund , Christopherd Scharer , Charlesh Mccauley , Stuti Mutneja , Troyd Randall , Christopherf Fucile , World Health Organization , Marnixe Heersink School Of Medicine , Division Of Clinical Immunology , Department Of Microbiology , Department Of Medicine Division Infectious Diseases , Immunology Institute , National Institutes Of Health , Informatics Institute ,

Memory B cell marker predicts long-lived antibody response to flu vaccine

Memory B cell marker predicts long-lived antibody response to flu vaccine
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Emory University , United States , Emory University School Of Medicine , Charlesh Mccauley , Troyd Randall , Christopherf Fucile , Alexanderf Rosenberg , Christopherd Scharer , Christopherm Tipton , Stuti Mutneja , Ignacio Sanz , Johne Bradley , Dfran Lund , Paula Goepfert , R Glenn King , Esther Zumaquero , Betty Mousseau , Department Of Medicine Division Infectious Diseases , Division Of Clinical Immunology , Immunology Institute , Department Of Microbiology , National Institutes Of Health , World Health Organization , Informatics Institute , University Of Alabama At Birmingham , Department Of Medicine ,

Crohn's disease patients have specific IgG antibodies to human bacterial flagellins

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IMAGE: Last year, researchers used a mouse model that included immune-reactive T cells from patients with Crohn s disease in a proof-of-principle demonstration that a flagellin-directed immunotherapy might provide similar benefits in.
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Credit: UAB
BIRMINGHAM, Ala. - Last year, Charles O. Elson, M.D., demonstrated a potential preventive treatment for Crohn s disease, a form of inflammatory bowel disease. He used a mouse model that included immune-reactive T cells from patients with Crohn s disease in a flagellin peptide-specific immunotherapy. This study provided proof-of-principle that a flagellin-directed immunotherapy might provide similar benefits in patients.
Now University of Alabama at Birmingham researchers have moved a step closer to possible clinical testing of this treatment, say Elson and co-first authors Katie Alexander, Ph.D., and Qing Zhao, M.D., Ph.D. Their study, published in the journal ....

United States , Peterj Mannon , Charleso Elson , Qing Zhao , Katie Alexander , Basili Hirschowitz , Alexanderf Rosenberg , Meagan Reif , National Institutes Of Health , Department Of Medicine Division Gastroenterology , University Of Alabama At Birmingham , Department Of Microbiology , Colitis Foundation Of America , Department Of Veterans Affairs , Department Of Medicine , Rainin Foundation , Medicine Division , Lennard Wayne Duck , Colitis Foundation , Veterans Affairs , National Institutes , Synergy Award , Endowed Chair , Medicine Health , Immunology Allergies Asthma , Internal Medicine ,