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ImmPrev Bio, Inc. Receives Exclusive License to Commercialize a Diagnostic Tool and Early-Stage Treatment for Crohn's Disease

ImmPrev Bio, Inc. Receives Exclusive License to Commercialize a Diagnostic Tool and Early-Stage Treatment for Crohn's Disease
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Immprev Bio , Charles Elson , Mike Goodrich , Basili Hirschowitz , Cascadia Drug Development Group , University Of Alabama At Birmingham , Ventures Life Science Fund , Immprev Bio Inc , Prev Bio , Receives Exclusive License , Diagnostic Tool , Early Stage Treatment , Chief Scientific Officer , First Avenue Ventures Life Science Fund , First Avenue Ventures , First Avenue ,

Crohn's disease patients have specific IgG antibodies to human bacterial flagellins

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IMAGE: Last year, researchers used a mouse model that included immune-reactive T cells from patients with Crohn s disease in a proof-of-principle demonstration that a flagellin-directed immunotherapy might provide similar benefits in.
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Credit: UAB
BIRMINGHAM, Ala. - Last year, Charles O. Elson, M.D., demonstrated a potential preventive treatment for Crohn s disease, a form of inflammatory bowel disease. He used a mouse model that included immune-reactive T cells from patients with Crohn s disease in a flagellin peptide-specific immunotherapy. This study provided proof-of-principle that a flagellin-directed immunotherapy might provide similar benefits in patients.
Now University of Alabama at Birmingham researchers have moved a step closer to possible clinical testing of this treatment, say Elson and co-first authors Katie Alexander, Ph.D., and Qing Zhao, M.D., Ph.D. Their study, published in the journal ....

United States , Peterj Mannon , Charleso Elson , Qing Zhao , Katie Alexander , Basili Hirschowitz , Alexanderf Rosenberg , Meagan Reif , National Institutes Of Health , Department Of Medicine Division Gastroenterology , University Of Alabama At Birmingham , Department Of Microbiology , Colitis Foundation Of America , Department Of Veterans Affairs , Department Of Medicine , Rainin Foundation , Medicine Division , Lennard Wayne Duck , Colitis Foundation , Veterans Affairs , National Institutes , Synergy Award , Endowed Chair , Medicine Health , Immunology Allergies Asthma , Internal Medicine ,

Potential preventative treatment demonstrated for Crohn's disease

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BIRMINGHAM, Ala. - A potential preventive treatment for Crohn s disease, a form of inflammatory bowel disease, has been demonstrated in a mouse model and using immune-reactive T cells from patients with Crohn s disease.
This research, led by University of Alabama at Birmingham researcher Charles O. Elson, M.D., professor of medicine, focused on a subset of T cells known as T memory, or Tm cells. The UAB researchers used a triple-punch treatment to remove Tm cells and increase the number of T regulatory, or Treg, cells. Both of these results were able to prevent colitis in a T cell transfer mouse model, and they had similar inhibitory effects on immune-reactive CD4-positive T cells isolated from Crohn s disease patient blood samples. ....

Peterj Mannon , Qing Zhao , Charleso Elson , Basili Hirschowitz , Katiel Alexander , Craigl Maynard , Fengyuan Huang , Colitis Foundation , Department Of Pathology , National Institutes Of Health , Informatics Institute , Department Of Genetics , Department Of Medicine , University Of Alabama At Birmingham , Science Immunology , National Institutes , Endowed Chair , குயிங் ழோ , பெருங்குடல் அழற்சி அடித்தளம் , துறை ஆஃப் நோயியல் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , தகவல் நிறுவனம் , துறை ஆஃப் ஜெநெடிக்ஸ் , துறை ஆஃப் மருந்து , பல்கலைக்கழகம் ஆஃப் அலபாமா இல் பர்மிங்காம் , அறிவியல் நோயெதிர்ப்பு ,

Potential preventative treatment demonstrated for Crohn's disease - News

This potential preventive treatment for Crohn’s disease was tested on a mouse model and on immune-reactive T cells from patients with Crohn’s disease.
A potential preventive treatment for Crohn’s disease, a form of inflammatory bowel disease, has been demonstrated in a mouse model and using immune-reactive T cells from patients with Crohn’s disease.
This research, led by University of Alabama at Birmingham researcher Charles O. Elson, M.D., professor of medicine, focused on a subset of T cells known as T memory, or Tm cells. The UAB researchers used a triple-punch treatment to remove Tm cells and increase the number of T regulatory, or Treg, cells. Both of these results were able to prevent colitis in a T cell transfer mouse model, and they had similar inhibitory effects on immune-reactive CD4-positive T cells isolated from Crohn’s disease patient blood samples. ....

Peterj Mannon , Qing Zhao , Charleso Elson , Basili Hirschowitz , Katiel Alexander , Craigl Maynard , Fengyuan Huang , Colitis Foundation , Department Of Pathology , National Institutes Of Health , Informatics Institute , Department Of Genetics , Department Of Medicine , University Of Alabama At Birmingham , Science Immunology , National Institutes , Endowed Chair , குயிங் ழோ , பெருங்குடல் அழற்சி அடித்தளம் , துறை ஆஃப் நோயியல் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , தகவல் நிறுவனம் , துறை ஆஃப் ஜெநெடிக்ஸ் , துறை ஆஃப் மருந்து , பல்கலைக்கழகம் ஆஃப் அலபாமா இல் பர்மிங்காம் , அறிவியல் நோயெதிர்ப்பு ,