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The complementarity of DDR, nucleic acids and anti-tumour immunity

Immune checkpoint blockade (ICB) immunotherapy is a first-line treatment for selected cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore, only a minority of patients with cancer benefit from ICB, and there is a lack of fully informative treatment response biomarkers. Selectively exploiting defects in DNA damage repair is also a standard treatment for cancer, spurred by enhanced understanding of the DNA damage response (DDR). DDR and ICB are closely linked—faulty DDR produces immunogenic cancer neoantigens that can increase the efficacy of ICB therapy, and tumour mutational burden is a good but imperfect biomarker for the response to ICB. DDR studies in ICB efficacy initially focused on contributions to neoantigen burden. However, a growing body of evidence suggests that ICB efficacy is complicated by the immunogenic effects of nucleic acids generated from exogenous DNA damage or endogenous processes such as DNA replication. Chemothera ....

South Korea , Twyman Saint Victor , Cell Biol , Transl Med , Ageing Dev , Cancer Res , Saint Victor , Acids Res ,

Not a disease: a global call for action urging revision of the ICD-11 classification of old age

Not a disease: a global call for action urging revision of the ICD-11 classification of old age
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International Classification Of Diseases , International Classification Of Disease , World Psychiatric Association , World Medical Association , International Association Of Gerontology , National Academies Of Medicine , International Classification , Ageing Dev , Frailty Aging , International Association , World Medical , Old Age Psychiatry , World Psychiatric ,

Telomere length and risk of idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease: a mendelian randomisation study

Telomere length and risk of idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease: a mendelian randomisation study
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United Kingdom , City Of , Nat Genet , Kralova Lesna , Davey Smith , British Lung Foundation , University Of Bristol , Global Lung Function Initiative , Lung Foundation , Natl Acad Sci United States , Respir Med , Transl Med , Psychol Sci , Mol Genet , Kingdom Biobank , Med Genet , Rev Physiol , Ageing Dev , Englj Med , Intern Med , ஒன்றுபட்டது கிஂக்டம் , நகரம் ஆஃப் , நாட் ஜெநெட் , டேவி ஸ்மித் , பிரிட்டிஷ் நுரையீரல் அடித்தளம் , பல்கலைக்கழகம் ஆஃப் பிரிஸ்டல் ,

Age and frailty in COVID-19 vaccine development

Age and frailty in COVID-19 vaccine development
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Norberto Duarte Getty , Gerontol Geriatr , Canadian Frailty Network , Elsevier Ltd , Ageing Dev , Top Gerontol Geriatr , View Large , Scientific Advisory Board , நோர்பர்டோ ட்வார்டே கெட்டி , முதுமைப்படுதல் தேவ் , பார்வை பெரியது ,