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Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

IgG antibodies are crucial for protection against invading pathogens. A highly conserved N-linked glycan within the IgG-Fc tail, essential for IgG function, shows variable composition in humans. Afucosylated IgG variants are already used in anti-cancer therapeutic antibodies for their elevated activity through Fc receptors (FcγRIIIa). Here, we report that afucosylated IgG (~6% of total IgG in humans) are specifically formed against enveloped viruses but generally not against other antigens. This mediates stronger FcγRIIIa responses, but also amplifies brewing cytokine storms and immune-mediated pathologies. Critically ill COVID-19 patients, but not those with mild symptoms, had high levels of afucosylated IgG antibodies against SARS-CoV-2, amplifying pro-inflammatory cytokine release and acute phase responses. Thus, antibody glycosylation plays a critical role in immune responses to enveloped viruses, including COVID-19. ....

Noord Holland , United States , United Kingdom , Uppsala Lan , Eteläuomen Läi , Assaymap Bravo Agilent , Bruker Daltonics , Santa Clara , Academic Medical Center , Reagent Program , Ethics Committee Of The University Amsterdam , Platelet Immunology Laboratory , Ge Healthcare , Afucosylated Igg Responses , Total Igg , Afucosylated Igg , Plasmad Dimer , Amsterdam Cohort Studies , Finnish Red Cross Blood , Medical Ethics Committee , Cytomegalovirus Igg , Measles Igg , Mumps Igg , Proteing Sepharose , Millipore Multiscreen , Agilent Technologies ,

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

Noord Holland , United States , United Kingdom , Uppsala Lan , Eteläuomen Läi , Bruker Daltonics , Assaymap Bravo Agilent , U Cytech Biosciences , Santa Clara , Academic Medical Center , European Union Seventh Framework Programme Highglycan , Immunity Institute , Netherlands National Institute For Public Health , Monitoring Foundation , Ethics Committee Of The University Amsterdam , Discovery Workbench Software , Ge Healthcare , Netherlands Organization For Scientific Research , Reagent Program , Amsterdam Health Service , Windows Graphpad Software Inc , Sanquin Blood Supply Foundation , Platelet Immunology Laboratory , Afucosylated Igg Responses , Total Igg , Afucosylated Igg ,

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

Noord Holland , United States , United Kingdom , Uppsala Lan , Eteläuomen Läi , Bruker Daltonics , Assaymap Bravo Agilent , U Cytech Biosciences , Santa Clara , Academic Medical Center , Reagent Program , Windows Graphpad Software Inc , Ethics Committee Of The University Amsterdam , Platelet Immunology Laboratory , Discovery Workbench Software , Ge Healthcare , Afucosylated Igg Responses , Total Igg , Afucosylated Igg , Plasmad Dimer , Amsterdam Cohort Studies , Finnish Red Cross Blood , Medical Ethics Committee , Cytomegalovirus Igg , Measles Igg , Mumps Igg ,