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Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity

Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

Kruskal Wallis , Mount Sinai Health System Fig , Stanford Hospital Center , Mount Sinai Health System , Mount Sinai , Polyclonal Igg , Afucosylated Igg ,

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

n = 80) from the Amsterdam Cohort Studies on HIV infection and AIDS (ACS) were used to analyze HIV-specific antibody glycosylation. Peripheral blood samples used to purify CMV-specific antibodies (
n = 102) were from same cohort as used for HPA-1a collected by the Finnish Red Cross Blood service, Platelet Immunology Laboratory, Helsinki, Finland and the HIV cohort described above. SARS-CoV-2 patient samples from ICU patients from the Amsterdam UMC COVID study group were included, as well as Sanquin blood donors found seropositive for SARS-CoV-2, and mild longitudinal samples from hospital workers monitored after potential exposure (
26). A summary of the patients demographics is found in table S1, and detailed patient treatments of the ARDS COVID-19 patients in table S2 (all requiring ventilation). The ACS have been conducted in accordance with the ethical principles set out in the declaration of Helsinki and all participants provided written informed consent. The study wa ....

Afucosylated Igg , Total Igg , மொத்தம் இக் ,

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

IgG antibodies are crucial for protection against invading pathogens. A highly conserved N-linked glycan within the IgG-Fc tail, essential for IgG function, shows variable composition in humans. Afucosylated IgG variants are already used in anti-cancer therapeutic antibodies for their elevated activity through Fc receptors (FcγRIIIa). Here, we report that afucosylated IgG (~6% of total IgG in humans) are specifically formed against enveloped viruses but generally not against other antigens. This mediates stronger FcγRIIIa responses, but also amplifies brewing cytokine storms and immune-mediated pathologies. Critically ill COVID-19 patients, but not those with mild symptoms, had high levels of afucosylated IgG antibodies against SARS-CoV-2, amplifying pro-inflammatory cytokine release and acute phase responses. Thus, antibody glycosylation plays a critical role in immune responses to enveloped viruses, including COVID-19. ....

Noord Holland , United States , United Kingdom , Uppsala Lan , Eteläuomen Läi , Assaymap Bravo Agilent , Bruker Daltonics , Santa Clara , Academic Medical Center , Reagent Program , Ethics Committee Of The University Amsterdam , Platelet Immunology Laboratory , Ge Healthcare , Afucosylated Igg Responses , Total Igg , Afucosylated Igg , Plasmad Dimer , Amsterdam Cohort Studies , Finnish Red Cross Blood , Medical Ethics Committee , Cytomegalovirus Igg , Measles Igg , Mumps Igg , Proteing Sepharose , Millipore Multiscreen , Agilent Technologies ,

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

Noord Holland , United States , United Kingdom , Uppsala Lan , Eteläuomen Läi , Bruker Daltonics , Assaymap Bravo Agilent , U Cytech Biosciences , Santa Clara , Academic Medical Center , European Union Seventh Framework Programme Highglycan , Immunity Institute , Netherlands National Institute For Public Health , Monitoring Foundation , Ethics Committee Of The University Amsterdam , Discovery Workbench Software , Ge Healthcare , Netherlands Organization For Scientific Research , Reagent Program , Amsterdam Health Service , Windows Graphpad Software Inc , Sanquin Blood Supply Foundation , Platelet Immunology Laboratory , Afucosylated Igg Responses , Total Igg , Afucosylated Igg ,

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

Noord Holland , United States , United Kingdom , Uppsala Lan , Eteläuomen Läi , Bruker Daltonics , Assaymap Bravo Agilent , U Cytech Biosciences , Santa Clara , Academic Medical Center , Reagent Program , Windows Graphpad Software Inc , Ethics Committee Of The University Amsterdam , Platelet Immunology Laboratory , Discovery Workbench Software , Ge Healthcare , Afucosylated Igg Responses , Total Igg , Afucosylated Igg , Plasmad Dimer , Amsterdam Cohort Studies , Finnish Red Cross Blood , Medical Ethics Committee , Cytomegalovirus Igg , Measles Igg , Mumps Igg ,