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Researchers Demonstrate How Defects in Mitochondria May Lead to Autism Spectrum Disorder


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Researchers Demonstrate How Defects in Mitochondria May Lead to Autism Spectrum Disorder
Researchers at Children’s Hospital of Philadelphia (CHOP) have demonstrated that autism spectrum disorder (ASD) may be caused by defects in the mitochondria of brain cells. The findings were published online by the Proceedings of the National Academy of Sciences.
Multiple studies have revealed hundreds of mutations associated with autism spectrum disorder, but there is no consensus as to how these genetic changes cause the condition. Biochemical and physiological analyses have suggested that deficiencies in mitochondria, the “batteries” of the cell that produce most of the body’s energy, might be a possible cause. Recent studies have shown that variants of mitochondrial DNA (mtDNA) are associated with autism spectrum disorder. ....

United States , University Of Pennsylvania , Douglasc Wallace , Us Department Of Defense , Division Of Child Neurology , Developmental Disabilities Research Center , Proceedings Of The National Academy Sciences , National Institutes Of Health , Accure Inc , National Academy , Epigenomic Medicine , Charles Barnett Endowed Chair , Pediatric Mitochondrial Medicine , Metabolic Diseases , Child Neurology , Tal Yardeni , Neurobehavior Testing Core , National Institutes , Children 039s Hospital Of Philadelphia , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , எங்களுக்கு துறை ஆஃப் பாதுகாப்பு , பிரிவு ஆஃப் குழந்தை நரம்பியல் , வளர்ச்சி குறைபாடுகள் ஆராய்ச்சி மையம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , தேசிய கலைக்கழகம் ,