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Venetoclax Elicits Responses in B-Cell Receptor–Pretreated CLL Regardless of Mutation Status

Treatment with single-agent venetoclax led to prolonged disease response in patients with chronic lymphocytic leukemia who had relapsed or become refractory to prior B-cell receptor inhibitors including ibrutinib and idelalisib, according to findings from a phase 2 study. ....

United States , Ohio State University , Jennifera Woyach , Newave Pharmacyclics , Leukemia Research Program , International Workshop , Ohio State Comprehensive Cancer Center , Division Of Hematology , Lancet Oncology , Treatment With Single Agent Venetoclax , Prolonged Disease Response In Patients With Chronic Lymphocytic Leukemia , Relapsed Or Refractory To Priorb Cell Receptor Inhibitors , 2023 International Workshop On Cll ,

Acalabrutinib Is Associated With Low Frequency of Cardiac Events Across 3 Randomized Trials in CLL

Administration of acalabrutinib to patients with chronic lymphocytic leukemia with or without cardiovascular disorders at baseline results in a numerically decreased incidence of overall treatment-related cardiac toxicities and a comparable safety profile vs comparator CLL therapies such as ibrutinib. ....

Rupal Oquinn , Perelman School Of Medicine , International Workshop , Perelman School , Patients With Chronic Lymphocytic Leukemia , Cardiovascular Disorders At Baseline , Treatment Related Cardiac Toxicities , Cll Therapies , 2023 International Workshop On Cll ,